Lo lus "osteoarthritis" txhais tau tias yog kab mob ntawm cov pob qij txha ntawm qhov degenerative-dystrophic xwm, nrog rau kev puas tsuaj rau cov nqaij mos ntawm cov pob txha pob txha.
Cov cim tseem ceeb ntawm cov kab mob pathological no yog mob hnyav thiab deformity ntawm pob qij txha. Xws li kev hloov pauv hauv tib neeg lub cev musculoskeletal inevitably ua rau kev ua haujlwm tsis txaus.
cov ntaub ntawv dav dav
Lub hauv paus ntawm kev hloov pauv ntawm degenerative-dystrophic hauv osteoarthritis yog pob txha mos puas nrog kev sib kis ntawm cov tshuaj tiv thaiv kab mob. Tias yog vim li cas tus kab mob no feem ntau hu ua arthrosis-mob caj dab. Ntxiv mus, cov ntsiab lus txhais xws li arthrosis, osteoarthritis, osteoarthritis thiab deforming arthrosis tau nthuav tawm raws li cov lus nyob hauv ICD.
Hauv kev kho mob, lo lus "osteoarthritis" feem ntau yog siv los hais txog kev loj hlob (hloov hom) kab mob ntawm cov pob qij txha synovial.
Hauv kev kho mob ntawm cov kab mob no, tshuaj feem ntau yog siv qhov ntawdpab txhawb rau cov txheej txheem ntawm regeneration ntawm cartilaginous cov ntaub so ntswg. Ib qho ntawm cov tshuaj no nrov thiab zoo yog Tazan ntsiav tshuaj. Analogues ntawm cov tshuaj no, nws muaj pes tsawg leeg, lub hauv paus ntsiab lus ntawm kev txiav txim, kev phiv thiab contraindications rau kev siv yuav tsum tau nthuav tawm hauv qab no.
Cov tshuaj muaj pes tsawg leeg, daim ntawv tso tawm, piav qhia thiab ntim
"Tazan" - ntsiav tshuaj coated nrog lub plhaub dawb lossis yuav luag dawb, muaj cov duab biconvex thiab oval (qhov ntxhib saum npoo tau txais).
Cov khoom xyaw nquag ntawm cov tshuaj no yog chondroitin sodium sulfate thiab glucosamine hydrochloride. Raws li rau excipients, uas tsis muaj molecular hnyav povidone, colloidal silicon dioxide, qos starch, calcium stearate, crospovidone, talc thiab ludipress yog siv raws li lawv (ntxiv kom tau ib lub suab nrov).
Cov khoom ntawm lub plhaub ntawm cov ntsiav tshuaj "Tazan" suav nrog cov khoom xws li propylene glycol, hypromellose, macrogol thiab titanium dioxide.
Cov tshuaj nyob rau hauv nqe lus nug mus muag hauv cov pob hlwv, uas tau muab tso rau hauv cov thawv ntawv. Tsis tas li ntawd, Tazan ntsiav tshuaj (90, 60 thiab 30 daim) muaj nyob rau hauv cov kaus poom polymer.
Lub hauv paus ntawm kev ua ntawm cov tshuaj
Raws li cov lus qhia, Tazan ntsiav tshuaj yog tsim los txhawb cov txheej txheem ntawm pob txha mos rov tsim dua tshiab. Cov khoom xyaw nquag ntawm cov tshuaj no (chondroitin sulfate thiab glucosamine) nquag koom nrog hauv kev sib txuas ntawm cov ntaub so ntswg, thiab tseem tiv thaiv cov txheej txheem ntawm kev puas tsuaj ntawm pob txha pob txha.
Kev siv cov exogenous glucosamine pab txhawm rau tsim cov pob txha mos matrix thiab muab kev tiv thaiv (tsis yog tshwj xeeb) pob txha mos los ntawm kev puas tsuaj tshuaj.
Hauv nws daim ntawv sulfate ntsev, glucosamine yog qhov ua ntej rau hexosamine. Raws li rau sulfate anion, nws yuav tsum tau rau synthesis ntawm glycosaminoglycans.
Lwm qhov tseem ceeb ntawm kev ua haujlwm ntawm glucosamine yog los tiv thaiv cov pob txha mos thiab cov pob txha mos los ntawm kev puas tsuaj metabolic, uas feem ntau tshwm sim los ntawm kev noj cov tshuaj tsis-steroidal anti-inflammatory thiab ntau yam glucocorticosteroids.
Ntxiv rau glucosamine, Tazan ntsiav tshuaj kuj muaj xws li cov khoom xyaw nquag xws li chondroitin sulfate. Txawm hais tias cov khoom no yog absorbed lawm los yog nyob rau hauv daim ntawv ntawm cov khoom sib cais, nws ua hauj lwm pab raws li ib tug auxiliary substrate rau tsim cov pob txha mos noj qab nyob zoo.
Raws li ib feem ntawm cov ntsiav tshuaj Tazan, chondroitin sulfate stimulates lub synthesis ntawm hom II collagen thiab proteoglycans, nrog rau kev tsim ntawm hyaluronon. Tsis tas li ntawd, cov tshuaj no pab tiv thaiv hyaluronon los ntawm enzymatic cleavage (los ntawm kev ua kom qeeb ntawm hyaluronidase) thiab los ntawm kev puas tsuaj ntawm cov dawb radicals. Tsis tas li ntawd, chondroitin sulfate stimulates lub mechanism ntawm pob txha mos kho thiab tswj cov qauv ntawm cov kua synovial. Hauv kev kho mob osteoarthritis, cov tshuaj no tshem tawm cov cim tseem ceeb ntawm tus kab mob thiab txo tus neeg mob xav tau cov tshuaj uas tsis yog-steroidal anti-inflammatory.
Pharmacokinetic nta ntawm cov tshuaj
Dab tsi yog cov tshuaj pharmacokinetic muaj nyob hauv cov tshuaj "Tazan 500"? Cov ntsiav tshuaj (500 mg, 60 daim) nrog glucosamine muaj cov nyhuv "thawj dhau" los ntawm lub siab. Lub bioavailability ntawm cov tshuaj no thaum noj qhov ncauj yog hais txog 25%.
Cov tshuaj uas tau hais tseg tau muab faib rau txhua qhov ntaub so ntswg. Txawm li cas los xij, nws qhov siab tshaj plaws yog pom nyob rau hauv daim siab, pob txha mos thiab ob lub raum. Kwv yees li 30% ntawm cov koob tshuaj tau txuas ntxiv mus ntev hauv cov leeg nqaij thiab pob txha.
Glucosamine yog tawm los ntawm ob lub raum (tsis hloov pauv) thiab ib nrab los ntawm txoj hnyuv. Ib nrab-lub neej ntawm cov khoom hauv nqe lus nug yog 68 teev.
Raws li chondroitin sulfate, thaum cov tshuaj no tau noj hauv qhov ncauj hauv ib koob ntawm 0.8 g (los yog ob koob tshuaj ntawm 0.4 g), nws cov concentration hauv cov ntshav nce zuj zus txhua hnub..
Qhov bioavailability ntawm cov khoom hauv nqe lus nug yog kwv yees li 12%. Yuav luag 20% thiab 10%, feem, ntawm qhov lees txais koob tshuaj chondroitin sulfate yog absorbed nyob rau hauv daim ntawv ntawm tsawg thiab siab molecular phaus derivatives. Cov tshuaj nquag hauv nqe lus nug yog metabolized los ntawm desulfurization, thiab tawm los ntawm lub raum system.
Lub neej ib nrab ntawm chondroitin sulfate yog 310 feeb.
Cov tshuaj rau qhov ncauj
Yuav ua li cas tus neeg mob tuaj yeem muab tshuaj Tazan ntsiav tshuaj? Kev tshuaj xyuas cov kws tshaj lij muaj cov ntaub ntawv hais tias xws listimulating lub regeneration ntawm pob txha mos, cov tshuaj yog tshwj xeeb tshaj yog zoo nyob rau hauv osteoarthritis ntawm lub I-III degree. Ib qho kev qhia zoo sib xws rau kev siv muaj cov lus qhia txuas nrog rau cov tshuaj.
Contraindications rau sau tshuaj
Tazan ntsiav tshuaj txwv tsis pub noj ntawm / hauv:
- hypersensitivity rau yeeb tshuaj;
- menyuam yaus, xws li mus txog 15 xyoos;
- pronounced disorders nyob rau hauv lub raum.
Nrog ceev faj, cov tshuaj no yog siv los ntshav, nyiam los ntshav, ntshav qab zib thiab mob hawb pob.
Tazan ntsiav tshuaj: cov lus qhia rau kev siv
Cov tshuaj no yog muab los ntawm qhov ncauj. Rau cov menyuam yaus hnub nyoog tshaj 15 xyoos thiab cov neeg laus, nws raug nquahu kom noj 1 ntsiav tshuaj 2 zaug hauv ib hnub. thaum thawj peb lub lis piam thiab 1 ntsiav tshuaj 1 r./d. lub sijhawm tom ntej. Nws yuav tsum nco ntsoov tias kev kho mob ruaj khov tiv thaiv keeb kwm yav dhau los ntawm kev noj cov tshuaj hauv nqe lus nug tsuas yog ua tiav tom qab 6 lub hlis ntawm kev kho mob tas li.
Side effects
Tazan tuaj yeem ua rau mob plab hnyuv, nrog rau mob epigastric, flatulence, cem quav lossis raws plab. Tsis tas li ntawd, thaum kho nrog tus neeg sawv cev no, kiv taub hau, mob taub hau, tawv nqaij ua xua, tsaug zog, mob hauv ob txhais ceg, tachycardia, peripheral edema, thiab insomnia feem ntau tshwm sim.
Kev Sib Tham Tshuaj
Cov tshuaj "Tazan" muaj peev xwm ua kom nqus tau cov tetracyclines, nrog rau txo cov nyhuvglucosamine thiab semi-synthetic penicillins.
Tus neeg sawv cev hauv qab kev txiav txim siab yog sib xws nrog glucocorticosteroids thiab cov tshuaj uas tsis yog-steroidal anti-inflammatory, txawm li cas los xij, tawm tsam keeb kwm ntawm nws siv, kev txhim kho cov nyhuv ntawm cov tshuaj antiplatelet, anticoagulants thiab fibrinolytics yog ua tau.
Analogues thiab tshuaj xyuas
Dab tsi tuaj yeem hloov cov tshuaj xws li "Tazan"? Cov kws tshaj lij hais tias cov tshuaj hauv qab no yog cov analogues ntawm cov tshuaj hais: Artra, Artrafik, Teraflex, Chondrogluxide thiab Chondroflex.
Raws li kev tshuaj xyuas txog cov tshuaj no, lawv tsis meej. Ntau tus neeg mob yws tias thaum noj cov ntsiav tshuaj Tazan, cov teebmeem tsis zoo los ntawm txoj hnyuv feem ntau tshwm sim. Hauv cov xwm txheej zoo li no, cov kws kho mob pom zoo kom txo cov koob tshuaj uas siv 2 zaug. Yog tias tsis muaj kev txhim kho, ces nws yog qhov zoo dua rau tshem tawm cov tshuaj.
Tsis tas li, kev tshuaj xyuas feem ntau hais tias tsis pom muaj txiaj ntsig zoo thaum noj Tazan. Cov kws kho mob ntseeg hais tias yog tias tsis muaj qhov tshwm sim tom qab kawm tiav kev kho mob (rau 4 lub lis piam), nws yog ib qho tsim nyog los daws qhov teeb meem ntawm kev qhia meej qhov kev kuaj mob.
