Koj paub dab tsi txog tshuaj zoo li Komfoderm? Cov lus qhia rau kev siv, nqe, tshuaj xyuas, analogues thiab cov yam ntxwv ntawm cov tshuaj no paub tsawg. Yog li ntawd, nyob rau hauv tsab xov xwm no, peb txiav txim siab los nthuav qhia tag nrho cov ntaub ntawv hais txog cov tshuaj no.
Form, composition and description
Comfoderm, cov lus qhia rau kev siv uas tau piav qhia hauv qab no, yog tsim nyob rau hauv daim ntawv ntawm ib tug dawb cream nrog ib tug tshwj xeeb tsw (tej zaum yuav tsis muaj nws, thiab kuj muaj ib tug creamy tint).
Cov khoom xyaw nquag hauv cov tshuaj no yog methylprednisolone aceponate thiab urea. Tsis tas li ntawd, muaj pes tsawg leeg ntawm cov tshuaj pleev ib ce muaj xws li auxiliary cov khoom xyaw, uas tau nthuav tawm nyob rau hauv daim ntawv ntawm cov kua paraffin, propylene glycol, polysorbate-80, carbomer interpolymer (hom A), trometamol, metipparahydroxybenzoate thiab purified dej.
Nyob zoo
Comfoderm Topical (Cream) yog dab tsi? Cov lus qhia rau kev siv qhia tias nws yog glucocorticosteroid thiab tus neeg sawv cev keratolytic tib lub sijhawm. Nws qhov kev txiav txim yog vim muaj cov yam ntxwv ntawm cov khoom siv nrog rau nwscompound. Xav txog lawv cov khoom kom ntxaws ntxiv.
Methylprednisolone aceponate yog ib qho hluavtaws, uas tsis yog-halogenated steroid. Thaum siv sab nraud, nws muaj peev xwm tiv thaiv kev ua xua thiab inflammatory ntawm daim tawv nqaij, nrog rau cov tshuaj tiv thaiv uas cuam tshuam nrog kev loj hlob ntxiv. Qhov kev raug mob no ua rau muaj kev txo qis hauv lub hom phiaj ntawm cov txheej txheem inflammatory (erythema, o, quaj) thiab cov kev xav (khaus khaus, khaus, mob, thiab lwm yam).
Nws tseem yuav tsum tau hais tias thaum siv cov tshuaj no ntawm cov tshuaj pom zoo, nws cov txiaj ntsig zoo rau tib neeg lub cev yog tsawg.
Tom qab siv sijhawm ntev thiab rov siv cov tshuaj methylprednisolone aceponate rau ntawm qhov chaw loj ntawm daim tawv nqaij (40-60%), nrog rau thaum nws siv rau hauv kev hnav khaub ncaws occlusive, cov neeg mob tsis muaj kev cuam tshuam ntawm cov qog adrenal, suav nrog theem ntawm cortisol tsis hloov.
Cov tshuaj nyob rau hauv nqe lus nug muaj peev xwm los khi rau intracellular glucocorticoid receptors, ua rau muaj ntau yam teebmeem lom. Hauv particular, cov txheej txheem tshuaj no ua rau induction ntawm macrocortin synthesis. Nyob rau tib lub sijhawm, qhov kawg inhibits kev tso tawm ntawm arachidonic acid thiab tsim cov inflammatory mediators xws li leukotrienes thiab prostaglandins.
Urea ua lub luag haujlwm dab tsi hauv Komfoderm? Cov lus qhia rau kev siv hais tias cov khoom no muaj moisturizing thiab keratolytic teebmeem. Nws khi dej, raws li qhov tshwm sim ntawm nws pab kom soften lub stratum corneum ntawm daim tawv nqaij.cover.
Ntxiv rau qhov ua haujlwm keratolytic, urea kuj nthuav tawm cov haujlwm proteolytic.
Kinetics
Y Puas yog Komfoderm cream absorbed? Cov lus qhia rau kev siv hais tias tom qab siv tus neeg sawv cev no, methylprednisolone aceponate yuav luag tam sim hydrolyzed nyob rau hauv dermis thiab epidermis.
Cov nquag nquag thiab tseem ceeb tshaj plaws ntawm cov tshuaj no yog 6alpha-methyl-prednisolone-17-propionate.
Qhov kev nqus ntawm daim tawv nqaij ntawm cov tshuaj hauv nqe lus nug yog nyob ntawm tus neeg mob lub cev thiab cov txheej txheem ntawm nws daim ntawv thov (tsis muaj lossis nrog kev hnav khaub ncaws occlusive).
Percutaneous absorption ntawm cov tshuaj nyob rau hauv cov neeg uas muaj psoriasis thiab atopic dermatitis yog hais txog 2.5%, uas yog me ntsis siab dua nyob rau hauv cov neeg ua haujlwm noj qab haus huv (kwv yees li 0.6-1.5%).
Thaum 6alpha-methylprednisolone-17-propionate nkag mus rau hauv cov hlab ntsha hauv lub cev, nws nrawm nrawm nrog glucuronic acid, tom qab ntawd nws tsis ua haujlwm.
Metabolites ntawm cov tshuaj hauv nqe lus nug raug tshem tawm feem ntau los ntawm ob lub raum, tom qab 16 teev. Lub active Cheebtsam ntawm cov tshuaj no tsis nyob rau hauv lub cev. Vim tias qhov nqus dej tsawg ntawm urea thaum siv cov tshuaj pleev ib ce, cov tshuaj tsw qab zoo li tsis muaj qhov cuam tshuam rau lub cev.
Kev qhia
Los ntawm Komfoderm (ointment) tshuaj yog dab tsi? Cov lus qhia rau kev siv muaj cov npe hauv qab no:
- microbial eczema;
- ua xua dermatitis(pin);
- neurodermatitis, atopic dermatitis;
- muaj tseeb eczema;
- kev sib cuag dermatitis;
- dyshidrotic eczema.
Hauv lwm lo lus, cov tshuaj hauv nqe lus nug tau muab rau cov kab mob ntawm daim tawv nqaij nrog kev ua txhaum ntawm keratinization, thiab tseem qhia tau tias muaj kev nkag siab zoo rau kev kho mob nrog tshuaj pleev glucocorticosteroids.
YContraindications
Comfoderm, cov lus qhia rau kev siv uas yuav tsum tau nyeem rau txhua tus neeg mob, yuav tsum tsis txhob siv thaum:
- hypersensitivity rau lub ntsiab ntawm cream;
- tuberculous lossis syphilitic txheej txheem hauv thaj tsam ntawm daim ntawv thov tshuaj;
- kab mob kis (xws li kab mob khaub thuas, kab mob sib kis);
- rosacea, perioral dermatitis nyob rau hauv daim ntawv thov ntawm cov tshuaj pleev;
- kev tshwm sim rau kev txhaj tshuaj;
- tsis muaj hnub nyoog.
Tshuaj "Komfoderm" (ointment): cov lus qhia rau kev siv
Tus nqi ntawm cov nyiaj nug yog hais txog 480-530 rubles. Cov tshuaj yog siv rau thaj tsam ntawm daim tawv nqaij nyob rau hauv ib txheej me me, ib hnub ib zaug.
Lub sijhawm ntawm kev kho mob tas li thiab niaj hnub nrog cov tshuaj no yuav tsum tsis pub tshaj 12 lub lis piam. Nws yuav tsum raug sau tseg tias kev kho mob ntawm daim tawv nqaij ntawm daim tawv nqaij yuav tsum tau ua 5 hnub.
Side effects
Cov kev phiv dab tsi tuaj yeem ua rau cov tshuaj "Comfoderm M2"? Cov lus qhia rau kev sivceeb toom tias cov teebmeem no tshwm sim tsawg heev. Raws li txoj cai, lawv pom lawv tus kheej nyob rau hauv daim ntawv ntawm cov tshuaj tiv thaiv hauv zos hauv qab no: khaus, erythema, kub hnyiab, tsim tawm pob vesicular.
Yog tias cov tshuaj tau siv ntau tshaj plaub lub lis piam lossis nyob rau thaj chaw loj ntawm daim tawv nqaij, tus neeg mob tuaj yeem tsim cov tawv nqaij atrophy lossis telangiectasia, nrog rau kev hloov pauv ntawm pob txuv, striae thiab cov kab mob hauv lub cev uas tshwm sim los ntawm kev nqus. ntawm corticosteroid.
Kuj qee zaum cov tshuaj hauv nqe lus nug ua rau hypertrichosis, folliculitis, tawv nqaij depigmentation, perioral dermatitis thiab kev tsis haum tshuaj.
Cov neeg siv tshuaj xyuas thiab analogues ntawm Komfoderma
Cov analogues ntawm cov tshuaj no suav nrog tsuas yog Advantan cream.
Cov neeg mob hais li cas txog Komfoderm tshuaj pleev? Raws li lawv cov kev txheeb xyuas, cov tshuaj nyob rau hauv nqe lus nug yog ib qho tshuaj zoo heev hauv zos. Nws siv tso cai rau koj tshem tawm ntau yam kab mob ntawm daim tawv nqaij, suav nrog eczema, neurodermatitis thiab dermatitis. Qee zaum, cov tshuaj no yog siv txawm rau psoriasis.
Qhov tsis zoo ntawm cov tshuaj pleev Komfoderm suav nrog nws tus nqi siab, nrog rau kev siv tsis tau thaum yau.
