Immunotherapy rau melanoma: tshuaj, nta thiab kev kho mob

Cov txheej txheem:

Immunotherapy rau melanoma: tshuaj, nta thiab kev kho mob
Immunotherapy rau melanoma: tshuaj, nta thiab kev kho mob

Video: Immunotherapy rau melanoma: tshuaj, nta thiab kev kho mob

Video: Immunotherapy rau melanoma: tshuaj, nta thiab kev kho mob
Video: მოციქულთა მოწოდება და ცხრა ნეტარება - საკვირაო ქადაგება - მღვდელი ბასილ მურმანიშვილი 2024, Lub Xya hli ntuj
Anonim

mob qog noj ntshav tau kuaj pom hauv 200,000 tus neeg hauv ib xyoos, thiab kwv yees li 70,000 ntawm lawv tuag. Raws li kev txheeb cais, cov lej no txuas ntxiv mus skyrocket. Raws li qhov no, peb tuaj yeem xaus tias cov kev kho mob uas twb muaj lawm tsis muaj txiaj ntsig txaus. Txhawm rau cawm ntau txhiab tus neeg txoj sia, nws yog qhov tsim nyog los tsim thiab siv lwm txoj hauv kev los tiv thaiv qog noj ntshav. Yog li, ib txoj hauv kev tshiab yog immunotherapy rau melanoma. Qhov no yuav tham hauv qab no.

Ua ntej koj yuav tsum paub seb nws yog tus kab mob dab tsi, yog vim li cas nws tshwm sim thiab tam sim no tab tom kho.

kab mob kev xav

Melanoma yog mob qog noj ntshav ntawm daim tawv nqaij uas tshwm sim los ntawm cov xim xim. Cov hlwb no yog lub luag haujlwm rau kev tsim cov melanin hauv lub cev - cov xim ntuj ntawm cov xim tsaus. Hom xim ntawm tus neeg nyob ntawm nws cov ntsiab lus ntau hauv lub cev.

Melanoma tshwm sim ib nrab ntawm cov mob ntawm ob txhais ceg, hauv 1/3 - ntawm caj npab thiab lub cev, qhov seem tshwm sim ntawm caj dab thiab lub ntsej muag.

About 65% ntawm tag nrho cov qog yog ib tug reborn mole.

melanoma theem 1
melanoma theem 1

Casmelanomas

Qhov feem ntau ua rau qog kev loj hlob yog raug rau lub teeb ultraviolet. Kwv yees li 90% ntawm tag nrho cov kab mob tshwm sim los ntawm qhov xwm txheej no. Kev raug lub hnub ntev ntev yam tsis muaj kev tiv thaiv ntawm daim tawv nqaij, nrog rau kev mus ntsib solariums ntau zaus, tuaj yeem ua lub zog rau qhov pib ntawm cov txheej txheem malignant hauv lub cev

Kev tiv thaiv tshav ntuj
Kev tiv thaiv tshav ntuj

Qhov kev hloov pauv tseem ceeb kuj ua lub luag haujlwm tseem ceeb. Cov neeg uas nws thawj cov txheeb ze (niam txiv, kwv tij) raug mob qog noj ntshav yog qhov txaus ntshai. Lawv tshwj xeeb tshaj yog yuav tsum tau ua tib zoo saib xyuas lawv txoj kev noj qab haus huv thiab tsis tu ncua kev kuaj mob tiv thaiv

melanoma theem 2
melanoma theem 2

txoj kev kho

Txoj hauv kev tseem ceeb ntawm kev kho mob qog noj ntshav muaj peb hom:

  1. Kev phais mob. Txoj kev tseem ceeb ntawm kev kho mob ntawm txhua theem ntawm tus kab mob, thaum lub qog tseem ua haujlwm. Raws li kev siv tshuaj loog dav dav, tus kws phais neeg ua haujlwm dav dav ntawm cov neoplasm nrog kev ntes cov ntaub so ntswg noj qab haus huv. Qhov no yog ua nyob rau hauv thiaj li yuav tiv thaiv kev loj hlob ntawm relapse. Tsis tas li ntawd, tsis tsuas yog tshem tawm ntawm daim tawv nqaij, tab sis kuj rog thiab nqaij nqaij, nrog rau ligaments thiab lwm yam.
  2. Tshuaj kho mob. Nws tuaj yeem raug kho raws li txoj hauv kev tseem ceeb ntawm kev kho mob lossis ntxiv rau kev phais. Cov tshuaj no muaj kev tiv thaiv kab mob qog noj ntshav thiab muaj peev xwm rhuav tshem cov qog. Cov tshuaj siv feem ntau yog Cisplatin, Karmustine, Vincristine.
  3. Kev kho hluav taws xob. Txoj kev no yog siv dav hauv kev xyaum oncological, thiab mob qog noj ntshav ntawm daim tawv nqaij- tsis muaj kev zam. Los ntawm kev cuam tshuam cov qog nrog gamma rays, nws muaj peev xwm deprive nws ntawm nws lub peev xwm loj hlob thiab yug me nyuam. Kev kho hluav taws xob tuaj yeem siv rau txhua theem ntawm tus kab mob, mus txog theem 4. Raws li txoj cai, tus neeg mob tau muab ntau chav kawm ua ke nrog kev so luv luv ntawm lawv.

Huab cua

Txawm tias muaj kev kho mob sib txawv rau melanoma, qhov kev cia siab rau cov neeg mob tsis zoo, thiab tib neeg tseem tuag los ntawm mob qog noj ntshav.

High ciaj sia taus tsuas yog hauv thawj (95%) thiab theem thib ob (75%).

Nyob rau theem thib peb, thaum lub qog tau metastasized rau cov qog ntshav hauv cheeb tsam, ib nrab ntawm cov neeg mob tswj kom kov yeej tus kab mob insidious. Yog tias ob peb lub qog ntshav qab zib raug cuam tshuam ib zaug, tsuas yog ib ntawm plaub tus ciaj sia.

Nyob rau theem kawg, thaum qhov mob qog nqaij hlav thib ob tau cuam tshuam txawm tias nyob deb ntawm lub cev, qhov kev cia siab tsis zoo (kev tuag mus txog 92%).

Tus kws kho mob muab tus neeg mob qhov kev poob siab
Tus kws kho mob muab tus neeg mob qhov kev poob siab

Txhua yam no ua rau cov kws tshawb fawb thiab kws kho mob nrhiav txoj hauv kev tshiab los tawm tsam cov kab mob phem.

Yog li, txoj kev tiv thaiv kab mob ntawm cov kab mob muaj mob tau dhau los ua qhov tshiab. Qhov zoo tshaj plaws yog qhov muaj peev xwm kho tau ntawm txhua theem ntawm tus kab mob.

Immunotherapy rau melanoma. Dab tsi yog?

Immunotherapy yog kev kho mob ntawm tus neeg mob qog noj ntshav nrog kev siv tshuaj uas muaj peev xwm kho qhov kev tiv thaiv kab mob, uas yog, lub cev tiv thaiv. Tag nrho cov no tso cai rau koj kom tsis txhob muaj kev loj hlob ntawm cov qog, thiab tiv thaiv nws qhov tshwm sim.rov qab los.

Vim qhov tseeb tias txoj kev no nyuam qhuav pib nkag mus rau hauv cov tshuaj, nws nyuaj rau unambiguously teb seb immunotherapy puas zoo rau melanoma. Txawm li cas los xij, cov txheeb cais uas muaj tam sim no paub meej tias muaj kev tiv thaiv kab mob siab ntawm cov tshuaj no.

Zoo li lwm yam kev kho mob, cov tshuaj tiv thaiv kab mob rau melanoma tuaj yeem ua rau muaj kev phiv ntau yam tsis xav tau. Txawm li cas los xij, lawv tsis tau hais tawm raws li kev siv tshuaj khomob.

Cov no suav nrog:

  • Ntaus, ntuav.
  • mob plab.
  • Nyob nkoos ntawm libs.
  • Txhawj xeeb.
  • Kev nyuaj siab, tsis txaus ntseeg.

Thiab puas tsim nyog ua tib zoo saib xyuas cov kev mob tshwm sim yog tias noj tshuaj tuaj yeem cawm txoj sia?

Ntau cov tshuaj siv rau kev tiv thaiv kab mob qog noj ntshav tau tshawb pom, tab sis hauv kev tiv thaiv kab mob melanoma, cov tshuaj no feem ntau siv, cov khoom xyaw tseem ceeb uas yog interferon-alpha thiab interleukin-2.

YInterferon-alpha

Nws siv tshwj xeeb tshaj yog xav tau tom qab kev phais kom tshem tawm cov qog loj. Immunotherapy nrog interferon rau melanoma pab tiv thaiv kev rov tshwm sim thiab kis ntawm metastases.

Cov tshuaj muaj ntau txoj haujlwm:

  1. Suppresses the process of proliferation (faib) of malignant cells.
  2. Tiv thaiv kev suav nrog cov hlwb noj qab haus huv thiab cov ntaub so ntswg hauv cov qog, yog li tso tseg nws txoj kev loj hlob.
  3. Lub luag haujlwm rau kev ua kom lub cev tiv thaiv kab mob. Xws li:
  • macrophages - lub luag haujlwm rau kev ntes thiabKev puas tsuaj ntawm cov hlwb txawv teb chaws thiab tshuaj lom;
  • T-lymphocytes - qhib kev tiv thaiv cellular thiab humoral.
  • Macrophages engulf lub malignant cell
    Macrophages engulf lub malignant cell

Cov tshuaj no muaj feem cuam tshuam rau kev tiv thaiv kab mob rau theem 2 melanoma, nrog rau thaum pib ntawm tus kab mob.

Cov kev kho mob thiab kev noj tshuaj tsuas yog xaiv los ntawm tus kws kho mob oncologist ntawm tus kheej rau txhua tus neeg mob. Txawm li cas los xij, ib qho kev tswj hwm interferon muaj ib qho zoo sib xws - thawj zaug, ntau npaum li cas tau sau rau thawj plaub lub lis piam, tom qab ntawd tus nqi ntawm cov tshuaj txo qis rau kev saib xyuas tus nqi.

Cov tshuaj muaj txiaj ntsig zoo hauv kev kho mob qog noj ntshav ntawm txhua yam. Tshwj xeeb, kev kho tshuaj tiv thaiv kab mob rau epithelioid melanoma nrog cov khoom siv interferon ua rau cov neeg mob muaj feem yuav rov zoo tag nrho.

Vim ntau npaum li cas, tus neeg tsim muaj ntau yam kev phiv, uas tau hais los saum toj no. Yog li, kev kho mob ntawm tus neeg mob qog noj ntshav nrog interferon tsuas yog ua hauv tsev kho mob thiab nyob rau hauv kev saib xyuas ntawm tus kws kho mob tshwj xeeb. Tom qab cov chav kawm tseem ceeb, tus neeg mob, raws li txoj cai, tau muab kev kho mob mus sij hawm ntev nrog cov tshuaj hauv kev saib xyuas ntau npaum li cas. Hauv qhov no, koj tuaj yeem kho tau tom tsev.

Interferon-alpha rau kev kho mob melanoma yog tsim los ntawm lub npe lag luam "Intron A". Cov tshuaj no yog tsim los ntawm Belgian kws tshuaj lub tuam txhab Schering-Plough Labo N. V. thiab yuav raug nqi tus neeg yuav khoom txog 7,000-11,000 rubles ib pob.

Tseem muaj cov tshuaj zoo sib xws: "Realdiron","Reaferon", "Laferon" thiab lwm yam.

Ntim "Roferon-A"
Ntim "Roferon-A"

Interleukin-2

Ib tshuaj tshwj xeeb uas tau qhia nws cov txiaj ntsig ntawm txhua theem ntawm tus kab mob. Yog li ntawd, "Interleukin-2" tuaj yeem muab tshuaj rau cov neeg mob uas muaj mob qog noj ntshav thib plaub.

Cov tshuaj nquag ntawm cov tshuaj yog cov protein uas tau tsim los ntawm lymphocytes. "Interleukin" txhawb kev tsim cov tshuaj tua kab mob uas paub txog thiab rhuav tshem cov kab mob malignant. Raws li qhov tshwm sim, cov qog nqaij hlav loj zuj zus thiab poob peev xwm los metastasize.

Nyob rau hauv lub khw muag tshuaj niaj hnub no, cov khoom lag luam muaj nyob rau hauv daim ntawv ntawm ntau lub npe lag luam uas txawv ntawm ib leeg hauv kev sib xyaw. Ntxiv nrog rau interleukin, lawv muaj:

  • Ymicroorganisms E.coli - "Bioleukin", "Teceleukin", "Proleukin";
  • yeast Saccharomyces cerevisiae - "Roncoleukin", "Albueikin".

Tus nqi ntawm cov tshuaj kuj siab thiab nyob ntawm qhov ntau npaum li cas. Piv txwv li, "Roncoleukin" nqi ntawm 2000-7000 rubles rau ib pob nrog peb ampoules.

Ntim "Roncoleukin"
Ntim "Roncoleukin"

Txhua yam tshuaj muaj ib yam zoo sib xws - lawv pab txhawb kev tsim cov cytokines, proteins, thaum tsis muaj lub cev tiv thaiv kab mob tsis tuaj yeem tawm tsam cov txheej txheem malignant.

Txoj kev tiv thaiv kab mob

  • Kev siv txoj kev kho no tsuas yog muab los ntawm tus kws kho mob oncologist.
  • Immunotherapy tuaj yeemraug tshuaj tsuas yog tom qab kev tshuaj ntsuam xyuas, xa cov kev kuaj sim rau cov neeg mob. Qhov no yuav ua rau cov kws kho mob muaj daim duab tiav ntawm tus kab mob, tus neeg mob txoj kev noj qab haus huv, nrog rau theem ntawm tus mob qog noj ntshav.
  • Kev phais kom tshem tawm cov qog yuav tsum yog qhov tseem ceeb ntawm kev kho mob. Tom qab ntawd, kev siv tshuaj tiv thaiv kab mob yog ua tau. Qhov no yuav ua rau tus neeg mob muaj feem yuav rov zoo tau ntau ntxiv.
  • Lub npe ntawm cov tshuaj, ntau npaum li cas thiab lub sijhawm ntawm chav kawm yog muab los ntawm tus kws kho mob ib leeg rau txhua tus neeg mob.
  • Kev kho mob yuav tsum tau ua hauv tsev kho mob, nyob rau hauv kev saib xyuas ntawm kws kho mob.
  • Nws tsis tuaj yeem lees txais los cuam tshuam kev kho mob sai sai, qhov no tuaj yeem ua rau txo qis hauv kev tiv thaiv thiab kev loj hlob ntawm tus kab mob ntau dua.
  • Thaum thiab tom qab kho, tus neeg mob yuav tsum noj ntau cov vitamins thiab minerals kom lub cev tiv thaiv.
  • Thaum kawg ntawm chav kawm, cov kws kho mob tshuaj xyuas tus neeg mob los saib xyuas kev kho mob zoo.

Cov txiaj ntsig ntawm kev tiv thaiv kab mob

Immunotherapy yog kev kho mob qog noj ntshav rau cov hluas. Txawm li cas los xij, nws twb tau tswj xyuas nws tus kheej, muaj ntau qhov zoo.

  • Txhim lub neej nyob rau hauv cov neeg mob uas mob qog noj ntshav siab thiab metastases txawm nyob rau hauv lub cev sib cais los ntawm cov qog.
  • Immunotherapy rau melanoma txhim kho txoj hauv kev rov qab los thaum kev phais kom tshem tawm qhov malignancy tsis tau.
  • Txhim kho cov ciaj sia ntawm cov neeg mob qog noj ntshav.

Qhov tsis zoo ntawm kev tiv thaiv kab mob rau melanoma

Raws li lwm yam kev kho mob qog noj ntshav, qhov kev kho no tsis yog yam tsis muaj qhov tsis zoo. Cov no suav nrog:

  • Indirect (los ntawm lub cev tiv thaiv kab mob) ua haujlwm. Qhov ntawd yog, cov tshuaj tsis cuam tshuam ncaj qha rau cov qog nqaij hlav cancer.
  • Hauv koob tshuaj ntau, cov tshuaj interleukin tuaj yeem ua rau ntau lub cev tsis ua haujlwm.
  • Lub sijhawm kho mob.
  • Kev xav tau kev kho mob tsis tu ncua. Txwv tsis pub, tus kab mob yuav rov zoo dua.
  • Qhov tsis muaj peev xwm kwv yees qhov tseeb cov lus teb ntawm cov qog nqaij hlav cancer rau kev kho mob. Hauv ib feem peb ntawm cov xwm txheej, tsis muaj qhov cuam tshuam. Qhov no tau piav qhia los ntawm qhov tseeb tias tsis muaj cov ntaub ntawv lub hom phiaj ntawm tus yam ntxwv ntawm kev tiv thaiv kab mob ntawm txhua tus neeg mob.
  • Kev xaiv tus kheej ntawm kev noj tshuaj raws li kev kuaj mob ntau ntawm tus neeg mob.
  • Kev siv tshuaj ntev ntev ua rau muaj kev tawm tsam ntawm lub cev tiv thaiv kab mob.

Zoo kawg

Tam sim no, muaj ntau txoj hauv kev kom tshem tau cov qog nqaij hlav ntawm daim tawv nqaij. Txawm li cas los xij, cov neeg mob uas tau kho nrog kev tiv thaiv kab mob rau melanoma yuav muaj txoj hauv kev zoo tshaj plaws ntawm kev rov zoo. Yog li ntawd, nws yog ib qho tseem ceeb heev uas yuav tau ua kom cov tshuaj nkag mus rau ntau yam ntawm cov neeg mob sai li sai tau. Thiab tej zaum ces qhov kev tuag ntawm oncology (tshwj xeeb yog los ntawm daim tawv nqaij mob cancer) yuav txo qis.

Pom zoo: