Nyob rau hauv tsab xov xwm peb yuav piv cov tshuaj insulins luv luv.
Rau yuav luag ib puas xyoo, kev tsim tshuaj hormonal rau cov neeg mob ntshav qab zib tau yog qhov tseem ceeb tshaj plaws hauv kev lag luam tshuaj. Ib lub hlis twg ntawm ib puas xyoo muaj ntau tshaj li tsib caug ntau hom tshuaj hypoglycemic. Vim li cas tus neeg mob ntshav qab zib yuav tsum txhaj tshuaj ultrashort insulin rau hauv lub cev ntau zaus hauv ib hnub? Cov tshuaj sib txawv li cas, suav npaum li cas?
Insulin thiab lawv lub sijhawm ua haujlwm
Tag nrho cov npe ntawm insulins tam sim no paub. Cov cim tseem ceeb ntawm cov tshuaj synthesized rau cov ntshav qab zib yog nws cov qeb, hom, tsim lub tuam txhab thiab cov txheej txheem ntim khoom.
Lub sijhawm ua haujlwm ntawm ultrashort insulin ntawm tib neeg lub cev yog txiav txim siab los ntawm ob peb yam: thaum insulin pib siv tom qab txhaj tshuaj; siab kawgnws concentration; tag nrho lub sijhawm ntawm cov nyiaj txij thaum pib mus txog rau thaum xaus.
txhais li cas? Cia peb kawm saib.
Ultra-luv insulin yog ib pawg ntawm cov tshuaj ntxiv rau lub sijhawm ntev, sib xyaw thiab nruab nrab. Yog tias koj kawm txog qhov nkhaus ntawm cov nyhuv ntawm ultra-ceev cov tshuaj hormones ntawm daim duab, koj tuaj yeem pom tias nws nce siab thiab sib cog lus zoo raws lub sijhawm axis.
Hauv kev xyaum, lub sijhawm ua haujlwm ntawm luv luv thiab ultrashort insulin nyob ntawm ntau yam, tsis yog ntawm qhov chaw txhaj tshuaj xwb:
- thaj chaw nkag mus ntawm cov tshuaj hypoglycemic (rau hauv cov ntshav capillary, hauv qab ntawm daim tawv nqaij, rau hauv cov leeg);
- zaws daim tawv nqaij hauv qhov chaw txhaj tshuaj (pinching thiab stroking nce tus nqi ntawm kev nqus);
- ambient thiab lub cev kub (txo ua rau cov txheej txheem qeeb dua, thiab nce, ntawm qhov tsis sib xws, nrawm dua);
- localization, tej zaum yuav muaj cov ntsiab lus ntawm cov tshuaj hauv cov ntaub so ntswg hauv qab daim tawv nqaij;
- tus neeg lub cev tiv thaiv kev kho.
Kev txiav txim siab npaum li cas yuav tsum tau them nyiaj rau cov carbohydrates noj hauv cov zaub mov, tus neeg mob yuav tsis xav txog qhov raug tshav ntuj lossis da dej sov, hnov cov tsos mob ntawm kev poob qis hauv qab zib. Hypoglycemia muaj cov tsos mob xws li tsis meej pem, kiv taub hau, thiab kev xav tsis muaj zog thoob plaws hauv lub cev.
Ob peb hnub tom qab txhaj tshuaj ultrashort insulin, nws cov khoom hauv qab ntawm daim tawv nqaij tshwm. Txhawm rau kom tsis txhob muaj qhov tshwm sim ntawm qhov tshwm sim ntawm hypoglycemia uas tuaj yeem ua rau tsis nco qab, tus neeg mob ntshav qab zib yuav tsum tau noj zaub mov nrog cov carbohydrates ceev uas muaj cov piam thaj, cov khoom qab zib "ntawm tes".cov khoom raws qib siab tshaj ntawm hmoov.
Qhov ua tau zoo ntawm kev txhaj tshuaj nrog pancreatic hormone yog txiav txim los ntawm qhov chaw ntawm nws qhov kev tua. Txog li 90% yog nqus los ntawm lub plab. Yog li, piv txwv li, los ntawm txhais ceg lossis caj npab - 20% tsawg dua.
Cov npe nrov tshaj plaws ntawm cov tshuaj insulin luv luv yuav tau teev tseg hauv qab no.
Cov spectrum dav dav insulins los ntawm cov tuam txhab sib txawv tuaj yeem hloov pauv. Humalog ultrashort insulin yog tsim nyob rau hauv Is Nrias teb thiab Asmeskas. Novorapid yog tsim los ntawm kev sib koom ua ke ntawm Danish-Indian tuam txhab Novo Nordix. Ob hom tshuaj yog tib neeg hom insulin. Thawj tus muaj ob txoj kev ntim khoom: hauv ib lub thawv ntawv thiab hauv lub vial. Cov tshuaj hormone "Apidra" yog tsim nyob rau hauv lub teb chaws Yelemees los ntawm lub tuam txhab "Sanofi-Aventis", nws yog nyob rau hauv syringe cwjmem. Txhua yam khoom siv hauv daim ntawv ntawm cov qauv tsim tshwj xeeb uas zoo li tus cwj mem tus cwj mem muaj qhov zoo tsis txaus ntseeg ntawm cov koob txhaj tshuaj thiab vials:
- lawv xav tau rau cov neeg uas tsis pom kev, txij li qhov ntau npaum li cas yog txiav txim siab los ntawm lub suab nyem;
- dhau ntawm lawv cov tshuaj tuaj yeem siv los ntawm khaub ncaws, hauv txhua qhov chaw pej xeem;
- koob yog nyias dua piv rau insulin.
Cov tshuaj uas tuaj yeem nkag mus rau Russia tau sau npe ua lus Lavxias. Hnub tas sij hawm (txog li ob xyoos - ib txwm) thiab cov hnub tsim khoom raug cim rau ntawm lub raj mis thiab ntim. Kev cia siab los ntawm cov tuam txhab tsim khoom hais txog cov khoom ib ntus. Cov lus qhia muaj nyob rau hauv cov pobQhov tseem ceeb theoretical tau qhia, thiab nws yog nyob rau ntawm lawv tias tus neeg mob ntshav qab zib yuav tsum tau coj.
Nws pib thaum twg?
Ultra-luv insulins pib ua tam sim ntawd, hauv feeb tom qab txhaj rau hauv qab ntawm daim tawv nqaij. Cov "luv" pib los ntawm 15 mus rau 30 feeb. Lub sijhawm ua haujlwm tau nce me ntsis. Tus neeg mob yuav hnov qhov txiaj ntsig siab tshaj plaws ntawm kev qhia cov tshuaj "superfast" hauv ib teev.
Lub sijhawm kawg ntawm qhov kawg yog ob peb teev. Nws ntog nyob rau lub sij hawm ntawm intensive digestion ntawm cov zaub mov nyob rau hauv lub plab, nkag mus rau cov piam thaj rau hauv cov ntshav raws li ib tug tshwm sim ntawm kev puas tsuaj ntawm complex carbohydrates. Kev nce hauv glycemia yog them los ntawm kev xa cov tshuaj insulin tag nrho yog tias qhov koob tshuaj tau raug teem tseg.
Ib qho kev ua tsis tu ncua tau tsim, uas yog raws li hauv qab no: kev nce hauv koob tshuaj kuj tseem cuam tshuam rau lub sijhawm ntawm kev cuam tshuam ntawm tus neeg sawv cev hypoglycemic, nyob rau hauv qhov ntau teev hauv cov lus qhia. Qhov tseeb tiag, cov tshuaj hormones ceev ceev yuav kav ntev txog plaub teev yog tias noj tsawg dua kaum ob units.
Ntawm qhov koob tshuaj ntau dua, lub sijhawm nce ntxiv ob teev. Ntau tshaj nees nkaum units ntawm ultrashort-acting insulin tsis pom zoo kom muab tshuaj rau ib zaug. Muaj kev pheej hmoo loj ntawm hypoglycemia. Cov tshuaj insulin ntau dhau yuav tsis nqus los ntawm lub cev, nws yuav tsis muaj txiaj ntsig thiab ua rau muaj kev phom sij.
"Nruab nrab" thiab "ntev" hom nyiaj tsis paub meej, vim lawv tau ntxiv tus ncua ntev. Hom ultrashort insulin txawv. Nws yog pob tshab thiab huv si, tsis muaj stains, inclusions thiab turbidity. Xws liCov cuab yeej sab nraud cais cov insulin txuas ntxiv thiab ultrashort.
Lwm qhov sib txawv tseem ceeb ntawm hom insulin yog kev ua tiav ntawm "luv" intramuscularly, intravenously thiab subcutaneously, thiab "ntev" - tsuas yog subcutaneously.
txwv tsis pub ua haujlwm
Mob ntshav qab zib yuav tsum tsis:
- siv cov khoom hnyav dhau lawm (ntau tshaj 2-3 lub hlis);
- yuav tshuaj hauv qhov chaw tsis tau lees paub;
- freeze.
Koj yuav tsum ceev faj nrog tus tsis paub, cov chaw tsim khoom tshiab. Nws raug nquahu kom khaws cov tshuaj hauv lub tub yees ntawm qhov kub ntawm +2 txog +8. Cov tshuaj insulin rau kev siv tam sim no yuav tsum tau khaws cia rau hauv chav sov kom haum rau kev khaws cia, tsis yog hauv tub yees.
Drug Comparison
Cov kws tshaj lij feem ntau sau cov tshuaj Actrapid, Humulin, Homoral, Rapid, Insuman.
Lawv yeej zoo ib yam hauv lawv qhov kev ua rau lub ntuj tsim. Lawv tsuas muaj qhov sib txawv xwb - lawv tuaj yeem siv rau ob hom ntshav qab zib hom thawj thiab thib ob. Tsis tas li ntawd, lawv tuaj yeem siv los ntawm cov neeg mob ketoacytosis thiab tom qab phais, thaum cev xeeb tub.
Cov tshuaj insulin luv luv uas nrov tshaj plaws yog Humalog, uas tsis tshua muaj tshwm sim thiab tau ua pov thawj tias muaj txiaj ntsig zoo.
Apidra thiab ultrashort insulin Novorapid raug tshuaj tsawg dua. Lawv yog cov tshuaj insulin glulisine lossis liproinsulin kua. Hauv lawv qhov kev ua, lawv txhua tus zoo ib yam li cov organic. Tam sim ntawd tom qab kev tswj hwm, cov ntshav qabzib txo qis thiab tus neeg mob zoo dua.
Special Applications
Qee tus neeg uas muaj lub suab circadian tshwj xeeb tsim cov tshuaj hormones ntau thaum kaj ntug: cortisol, glucagon, adrenaline. Lawv yog cov antagonists ntawm cov tshuaj insulin. Hormonal secretion vim tus yam ntxwv ntawm tus kheej tuaj yeem tshwm sim sai thiab hnyav. Tus mob ntshav qab zib muaj hyperglycemia thaum sawv ntxov. Qhov no syndrome tshwm sim ntau zaus. Nws yuav luag tsis yooj yim sua kom tshem tawm nws. Tib txoj kev tawm ntawm qhov xwm txheej no yog txhaj tshuaj insulin luv luv txog li rau lub hlis, ua rau sawv ntxov.
Feem ntau, kev kho sai sai yog ua ua ntej noj mov. Vim muaj kev ua haujlwm siab, koj tuaj yeem txhaj ob lub sijhawm noj mov thiab tam sim ntawd tom qab. Lub sijhawm luv luv ntawm cov nyhuv ntawm cov tshuaj insulin yuam tus neeg mob ua ntau qhov kev txhaj tshuaj thaum nruab hnub, ua raws li kev tsim tawm ntawm lub txiav rau kev noj cov khoom carbohydrate. Los ntawm cov zaub mov, mus txog 5-6 zaug.
Txhawm rau tshem tawm cov kev cuam tshuam loj hauv metabolic hauv coma lossis pre-coma xeev, nrog rau kev kis kab mob thiab kev raug mob, kev npaj ultrashort yog siv yam tsis muaj kev sib txuas nrog lub sijhawm ntev. Los ntawm txoj kev ntawm glucometer, uas yog, ib qho cuab yeej rau kev txiav txim siab qib qab zib, lawv saib xyuas glycemia thiab rov ua kom tus kab mob decompensation.
Tsis yog txhua tus paub lub npe ntawm cov insulins luv luv. Lawv tau tham hauv kab lus.
Ntawm ntawm kev suav cov koob tshuaj ntawm ultra-ceev insulin
Kev txiav txim siab ntawm koob tshuaj yog nyob ntawm kev ua haujlwm ntawm pancreas los tsim nws tus kheej insulin. Nws lub peev xwm yog qhov yooj yim rau kev sim. Nws ntseeg tau tias lub cev endocrine hauv lub xeev noj qab haus huv tsim cov tshuaj hormones ib hnub twg nws yuav siv 0.5 units ib kilogram ntawm qhov hnyav. Qhov ntawd yog, yog tias tsim nyog, rau cov neeg mob ntshav qab zib uas hnyav 70 kg kom them nyiaj rau 35 units lossis ntau dua, peb tuaj yeem tham txog qhov ua tiav ntawm cov txiav ua tiav.
Ultra-luv insulin hauv qhov no yog xav tau, nrog rau cov tshuaj insulin ntev, hauv cov piv txwv hauv qab no: 40 txog 60 lossis 50 txog 50.
Qhov kev xaiv tau raug txiav txim los ntawm tus kws kho mob endocrinologist. Yog hais tias tus txiav tau poob ib feem ntawm lub peev xwm los tiv nrog xws li ib tug muaj nuj nqi, yuav tsum tau ib tug kom raug xam.
Lub cev xav tau "superfast" thaum nruab hnub kuj txawv. Rau pluas tshais thaum sawv ntxov, koj xav tau ob zaug ntau npaum li cov khob cij noj, thaum tav su - ib thiab ib nrab, thaum yav tsaus ntuj - tib tus nqi. Nws yog ib qho tsim nyog yuav tsum coj mus rau hauv tus account cov kev ua si kis las thiab kev ua haujlwm lub cev ua los ntawm tus neeg mob. Yog tias qhov load me me, qhov koob tshuaj insulin feem ntau tsis hloov pauv.
Thaum lub cev tsim, piv txwv li, nws raug nquahu kom noj txog plaub lub khob cij ntxiv tiv thaiv keeb kwm yav dhau los ntawm glycemia.
Daim ntawv thov hauv kev tsim lub cev
Nyob rau hauv lub teb ntawm bodybuilding, xws li cov cuab yeej raws li ib tug tseem ceeb anabolic nyhuv yog nquag siv, uas yog raws li nram no: hlwb nqus amino acids ntau active; protein biosynthesis nce ntau.
Y Nyob hauv lub cev tsim, ultrashort-acting insulinkuj tau siv. Cov tshuaj pib ua 5-10 feeb tom qab kev tswj hwm. Ntawd yog, kev txhaj tshuaj yuav tsum tau nqa tawm ua ntej noj mov, lossis tam sim tom qab nws. Qhov siab tshaj plaws ntawm cov tshuaj insulin yog pom tom qab 120 feeb tom qab kev tswj hwm. Cov tshuaj zoo tshaj plaws yog Actrapid NM thiab Humulin Regular.
Ultra-luv insulin hauv kev tsim lub cev tsis cuam tshuam rau kev ua haujlwm ntawm lub siab thiab lub raum, nrog rau lub zog.
Tiv thaiv lipodystrophy
Tus neeg mob ntshav qab zib yuav tsum tau saib xyuas kev tiv thaiv ntawm lipodystrophy. Nws yog raws li kev ua tsis tiav ntawm kev tiv thaiv kab mob, ua rau kev puas tsuaj ntawm fiber ntau hauv qab ntawm daim tawv nqaij. Cov tsos mob ntawm qhov chaw atrophied vim yog kev txhaj tshuaj ntau zaus tsis cuam tshuam nrog kev siv tshuaj ntau lossis nyiaj them tsis zoo rau ntshav qab zib.
Insulin edema, ntawm qhov tsis sib xws, yog qhov tsis tshua muaj teeb meem ntawm cov kab mob endocrine. Txhawm rau kom tsis txhob hnov qab txog qhov chaw txhaj tshuaj, koj tuaj yeem siv lub tswv yim uas lub plab (caj npab, ceg) muab faib ua ntu ntawm hnub ntawm lub lim tiam. Tom qab ob peb hnub, daim tawv nqaij npog ntawm thaj chaw punctured rov qab zoo heev.
Dab tsi yog qhov zoo lossis qhov tsis zoo ntawm ultrashort insulin rau ntshav qab zib?
pros and cons
Thaum piv nrog cov tib neeg luv luv ntawm cov tshuaj insulin, nws cov khoom luv luv luv tuaj yeem raug sau tseg qhov tsis zoo thiab qhov zoo. Lawv muaj qhov ua tiav ua ntej, tab sis tom qab ntawd lawv cov ntshav yuav txo qis dua yog tias koj txhaj tshuaj insulin luv luv. Txij li thaum ultrashort insulin muaj qhov nce sai dua, nws nyuaj rau paub tias yuav noj ntau npaum li cas carbohydrate thiaj li yuav tsum tau noj.normalization ntawm ntshav qab zib. Cov txiaj ntsig zoo ntawm cov tshuaj insulin luv luv yog ntau dua nyob rau hauv txoj kab nrog kev nqus ntawm cov zaub mov los ntawm lub cev dua li ua raws li kev noj zaub mov tsawg-carbohydrate los tswj ntshav qab zib.
Tab sis muaj lwm sab. Kev txhaj tshuaj insulin luv luv yog ua tiav 40-45 feeb ua ntej noj mov. Yog tias koj pib noj sai dua, ces hom insulin no yuav tsis muaj sijhawm los ua, thiab cov ntshav qab zib yuav nce siab. Ultrashort newest hom insulin ua sai dua, nyob rau hauv 10-15 feeb tom qab txhaj tshuaj, thiab qhov no yooj yim heev, vim hais tias ib tug neeg tsis paub ua ntej raws nraim lub sij hawm nws yuav tsum noj. Piv txwv li, thaum noj mov hauv tsev noj mov. Thaum ua raws li kev noj zaub mov tsawg-carbohydrate, nws feem ntau pom zoo kom siv cov tshuaj insulin luv luv ua ntej noj mov. Koj yuav tsum khaws cov tshuaj insulin luv luv ntawm tes yog tias qhov xav tau tshwm sim. Kev xyaum qhia tau hais tias ultrashort insulin muaj qhov cuam tshuam tsis zoo rau cov ntshav qab zib ntau dua li insulin luv. Lawv qhov kev txiav txim siab tsawg dua txawm tias thaum txhaj tshuaj tsawg, xws li hauv cov neeg mob ntshav qab zib noj cov zaub mov uas tsis muaj carbohydrate, thiab tshwj xeeb tshaj yog ntawm cov koob tshuaj siab. Tsis tas li ntawd, koj yuav tsum nco ntsoov tias hom luv luv ntawm cov tshuaj insulin muaj zog ntau dua li cov luv luv. Ib chav tsev ntawm Humalog yuav txo cov suab thaj kwv yees li 2.5 npaug ntau dua piv rau ib chav ntawm insulin luv. Apidra thiab Novorapid yog 1.5 npaug zog dua li insulin luv. Yog li, tus nqi ntawm "Humalog" yuav tsum sib npaug rau ib feem peb ntawm cov tshuaj insulin luv luv, "Apidra" lossis "NovoRapida" - ob feem peb. Qhov no yog cov ntaub ntawv qhiarefined experimentally.
Tam sim no peb paub tias cov insulins twg yog ultrashort.
Lub hom phiaj tseem ceeb yog kom txo qis lossis tiv thaiv kom tsis txhob dhia hauv qab zib tom qab noj mov. Txhawm rau ua qhov no, kev txhaj tshuaj yog muab ua ntej noj mov nrog cov npoo ntawm lub sijhawm txaus rau qhov pib ntawm cov tshuaj insulin. Ntawm ib sab, tib neeg xav txo cov ntshav qab zib tsuas yog thaum lub sijhawm zom zaub mov pib nce nws. Txawm li cas los xij, yog tias kev txhaj tshuaj ntxov dhau lawm, cov piam thaj yuav poob sai dua li nws tau tsa los ntawm cov zaub mov. Kev xyaum qhia tau hais tias nws yog ntshaw kom txhaj tshuaj insulin luv luv li 40-45 feeb ua ntej noj mov uas tsis muaj carbohydrates. Qhov tsuas yog qhov tshwj xeeb yog cov neeg mob uas muaj kev txhim kho ntshav qab zib gastroparesis - txo cov plab hnyuv plab tom qab noj mov. Tsis tshua muaj neeg mob ntshav qab zib tuaj nyob rau hauv leej twg, rau qee yam, cov tshuaj insulin luv luv tshwj xeeb yog maj mam nqus mus rau hauv cov hlab ntsha. Lawv raug yuam kom txhaj tshuaj ib teev thiab ib nrab ua ntej noj mov. Nws tsis xis nyob heev. Nyob rau hauv rooj plaub no, koj yuav tsum tau siv qhov tseeb ultra-luv npaj, ntawm cov ceev tshaj plaws yog Humalog.
Ultra-short insulin nqi
Tus nqi ntawm cov tshuaj insulin yog los ntawm 1700 rubles. rau ntim. Nws kim heev. Tus nqi nyob ntawm thaj av thiab lub khw muag tshuaj.
