Cov tshuaj "Fluconazole" yog tshuaj tua kab mob los ntawm qeb ntawm triazole derivatives. Cov tshuaj yog tsim los ntawm Lavxias teb sab kws lub tuam txhab CJSC VERTEX, uas nyob rau hauv St. Kev tshuaj xyuas ntawm "Fluconazole" los ntawm "Vertex" yuav nthuav tawm hauv qab no.
Kev sib xyaw thiab ntau npaum li cas
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov tshuaj ntsiav, cov tshuaj nquag yog fluconazole ntawm ib koob ntawm 50 mg lossis 150 mg. Fluconazole tsis muaj cov ntsiav tshuaj tso tawm.
Raws li cov khoom siv hauv kev tsim khoom siv: polyvinylpyrrolidone (povidone), pob kws hmoov txhuv nplej siab, colloidal silicon dioxide (aerosil), sodium lauryl sulfate, lactose, calcium stearate. Rau cov tshuaj ntsiav ntawm koob tshuaj 50 mg, gelatin, titanium dioxide, azorubine dye, daj dye - hnub poob yog siv, thiab rau Fluconazole, ua nyob rau hauv ib koob ntawm 150 mg los ntawm Vertex, titanium dioxide thiab gelatin yog siv. Gelatin nyuaj capsules - nrog lub cev dawb, txiv kab ntxwv cap, lawvcov ntsiab lus - compacted loj los yog hmoov dawb los yog yellowish hue.
tshuaj muaj txiaj ntsig
Raws li peb tau qhia los ntawm cov lus qhia rau kev siv, "Fluconazole" los ntawm "Vertex" yog ib chav kawm ntawm triazole tshuaj tiv thaiv kab mob. Nws yog ib qho muaj zog xaiv inhibitor ntawm fungal cell enzyme 14-α-demethylase. Cov tshuaj no tiv thaiv kev hloov pauv ntawm lanosterol rau hauv ergosterol, lub ntsiab tseem ceeb ntawm cov kab mob fungal.
Tsis yog txhua tus paub vim li cas cov ntsiav tshuaj Fluconazole pab. Cov tshuaj tau nce kev ua haujlwm hauv opportunistic mycosis, tshwj xeeb, provoked los ntawm Candida spp. (Candida tropicalis, Candida albicans), Microsporum spp., Cryptococcus neoformans, Trichophyton spp. Tsis tas li ntawd, cov kev ua ntawm lub ntsiab tivthaiv tau sim ntawm cov qauv ntawm endemic mycoses, nrog rau cov kab mob tshwm sim los ntawm Blastomyces dermatidis, Coccidioides immitis thiab Histoplasma capsulatum. Txawm li cas los xij, histoplasmas, blastomycetes, sporotrix thiab paracoccidioides tsis tshua nkag siab rau fluconazole dua li lwm cov azoles.
Indications for prescription
Cov tshuaj "Fluconazole" los ntawm lub tuam txhab "Vertex" yog sau rau kev kho mob ntawm cov kab mob hauv qab no:
- cryptococcosis, suav nrog cryptococcal meningitis thiab lwm qhov chaw ntawm tus kab mob no (dawb tawv nqaij, ntsws) ob qho tib si hauv cov neeg mob uas muaj lub cev tiv thaiv kab mob thiab nrog ntau hom kev tiv thaiv kab mob (AIDS, hloov pauv hauv nruab nrog cev);
- generalized candidiasis, suav nrog candidemia, tshaj tawm candidiasis thiab lwm hom kab mob candidiasisKev kis kab mob (kab mob ntawm endocardium, peritoneum, qhov muag, tso zis thiab ua pa);
- mucosal candidiasis, piv txwv li, pharynx thiab qhov ncauj kab noj hniav (xws li atrophic candidiasis ntawm qhov ncauj mucosa vim hnav prostheses), bronchopulmonary non-invasive candidiasis, candiduria, cutaneous candidiasis;
- tiv thaiv kev rov tshwm sim ntawm oropharyngeal candidiasis hauv cov neeg mob AIDS;
- mycosis ntawm daim tawv nqaij (pawg, lub cev, ko taw);
- Yonychomycosis, pityriasis versicolor;
- daim tawv nqaij candidiasis;
- genital candidiasis: mob ntev thiab mob qhov chaw mos candidiasis ntawm hom rov tshwm sim, nrog rau kev siv tshuaj tiv thaiv kom txo tau qhov zaus ntawm tus kab mob no (3 lossis ntau dua ib xyoos);
- tiv thaiv kab mob fungal nyob rau hauv cov neeg mob uas muaj oncological neoplasms uas yog predisposed rau fungal kab mob vim hluav taws xob kho los yog kev kho mob nrog cytostatics;
- candidal balanitis;
- dub kab mob mycoses, suav nrog histoplasmosis thiab coccidioidomycosis.
YContraindications
Fluconazole (Vertex) ntsiav tshuaj yog contraindicated nyob rau hauv cov xwm txheej hauv qab no:
- siab rhiab heev rau fluconazole, lwm yam tshuaj los yog azole tebchaw;
- sib xyaw siv terfenadine thiab cov tshuaj no (tawm tsam keeb kwm yav dhau los ntawm kev siv tas li ntawm fluconazole ntawm qhov ntau npaum ntawm 400 mg lossis ntau dua ib hnub), astemizole lossis cisapride thiab lwm yam tshuaj uas ncua sijhawm Q-T thiab ua rau muaj kev pheej hmoo ntawm kev loj hlob.kev hloov hauv lub plawv dhia;
- lactation;
- Kuv muaj 3 xyoos.
Qhov no yuav tsum tau txiav txim siab ua ntej teem sijhawm.
Kev txais tos zoo
Cov tshuaj tau sau tseg nrog ceev faj thaum lub siab tsis ua haujlwm, lub raum tsis ua haujlwm, nrog cov tsos ntawm pob liab liab thaum noj cov tshuaj hauv cov neeg mob uas muaj kab mob / kab mob fungal los yog muaj kab mob loj. Kev ceev faj yuav tsum tau saib xyuas thaum noj fluconazole thiab terfenadine ntawm cov koob tshuaj saum toj no, vim qhov no tuaj yeem ua rau muaj feem cuam tshuam rau cov neeg mob uas muaj kev pheej hmoo (electrolyte imbalance, organic plawv pathologies, ib txhij siv tshuaj uas ua rau arrhythmia). Kev tshuaj xyuas ntawm Fluconazole los ntawm Vertex yuav tsum tau nyeem ua ntej.
Thaum cev xeeb tub thiab lactation
Kev siv tshuaj thaum cev xeeb tub yog qhov tsis tsim nyog, tshwj tsis yog muaj kev phom sij rau lub neej ntawm cov kab mob fungal.
Cov tshuaj nquag ntawm cov tshuaj muaj nyob hauv cov kua mis tib yam li hauv cov ntshav, yog li nws siv thaum lactation yog qhov tsis xav tau.
Cov lus qhia rau kev siv
Cov tshuaj yog noj hauv qhov ncauj, noj txhua hnub nyob ntawm qhov hnyav thiab qhov xwm txheej ntawm tus kab mob fungal.
Rau cov kab mob cryptococcal thiab cryptococcal meningitis, 400 mg yog sau rau thawj hnub, tom qab ntawd kev kho mob txuas ntxiv ntawm koob tshuaj 200 mg ib hnub rau 10-12 lub lis piam.
Rau kev tshaj tawm candidiasis, candidemia thiab lwm yam kab mob kis kab mob, qhov ntau npaum li cas yog400 mg rau thawj hnub, thiab tom qab ntawd - 200 mg rau tsawg kawg 2 lub lis piam.
Rau oropharyngeal candidiasis, cov tshuaj tau sau tseg ntawm 50-100 mg ib hnub ib zaug, txog 14 hnub.
Rau atrophic candidiasis - 50 mg ib hnub twg 1 zaug, 2 lub lis piam ua ke nrog tshuaj tua kab mob hauv zos.
Nrog rau lwm qhov chaw ntawm cov kab mob candidiasis, tshwj tsis yog rau qhov chaw mos (esophagitis, tsis muaj kab mob bronchopulmonary lesions, candiduria, fungal lesions ntawm daim tawv nqaij thiab mucous daim nyias nyias), koob tshuaj zoo yog 50-100 mg ib hnub twg, 30 hnub. Nyob rau hauv cov ntaub ntawv hnyav ntawm cov kab mob no, qhov ntau npaum yog nce.
Fluconazole siv li cas rau cov poj niam thrush?
Rau qhov chaw mos candidiasis, cov tshuaj yog noj ib zaug ntawm ib koob ntawm 150 mg, rau daim tawv nqaij mycoses - 150 mg ib lub lis piam 1 zaug, rau pityriasis versicolor - 300 mg ib zaug ib lub lim tiam. "Fluconazole" los ntawm tus ntsia thawv pwm yog siv 150 mg 1 zaug hauv ib lub lis piam. Nrog rau qhov sib sib zog nqus mycosis, cov tshuaj tau muab tshuaj ntawm 200-400 mg ib hnub rau 2 xyoos.
Rau kev tiv thaiv ntawm candidiasis, qhov pom zoo koob tshuaj ntawm fluconazole yog 50-400 mg ib hnub ib zaug. Rau cov neeg mob uas xav tias mob hnyav lossis ntev ntev neutropenia, qhov koob tshuaj zoo tshaj plaws yog 400 mg 1 zaug hauv ib hnub.
Side effects
Raws li kev tshuaj xyuas, "Fluconazole Vertex" tuaj yeem ua rau muaj kev phiv xws li:
- Digestive system: saj hloov pauv, tsis qab los noj mov, dyspepsia, raws plab, tsam plab, mob plab, nce kev ua haujlwm.daim siab enzymes thiab kev hloov pauv hauv nws qhov kev ua haujlwm tsis zoo (hyperbilirubinemia, jaundice, hepatocellular necrosis, nce kev ua haujlwm ntawm aspartic aminotransferase, alanine aminotransferase thiab alkaline phosphatase, kab mob siab), suav nrog kev tuag..
- CNS: mob taub hau, kiv taub hau, convulsions.
- cov kab mob hematopoietic: neutropenia, agranulocytosis, hematological ntshawv siab (thrombocytopenia thiab leukopenia).
- Cov hlab plawv: ECG QT ncua ntev, ventricular flutter / flicker.
- Cov tshuaj tsis haum: exudative erythema multiforme, daim tawv nqaij ua pob ua pob, epidermal lom necrolysis, bronchial hawb pob, tshuaj tiv thaiv anaphylactoid.
- Lwm yam: hloov lub raum ua haujlwm, hypercholesterolemia, hypokalemia, baldness, hypertriglyceridemia.
Kev Sib Tham Tshuaj
Ib koob tshuaj ib zaug hauv kev kho mob ntawm qhov chaw mos candidiasis (thrush) tsis nrog kev cuam tshuam loj. Txawm li cas los xij, thaum siv cov tshuaj ntau dua nrog rau lwm cov tshuaj, cov tshuaj hauv qab no tuaj yeem ua tau:
- Nrog terfenadine, astemizole thiab cisapride: Ua kom cov ntshav plasma ntau ntxiv ntawm cov tshuaj no, uas tuaj yeem ua rau QT ncua sij hawm ntev thiab ua rau mob plawv mob hnyav. Fluconazole hauv daim siab inhibits enzymes ntawm P450 system, txo cov metabolism ntawm cov tshuaj no.
- Nrog rau kev siv ua ke ntawm fluconazole thiab warfarin, lub sijhawm prothrombin tau ntev, yog li ntawd, nrog rau kev sib xyaw ntawm cov tshuaj no, kev tswj hwm qhov no.qhov taw qhia.
- Fluconazole ncua ib nrab-lub neej ntawm cov tshuaj tiv thaiv qhov ncauj hypoglycemic (sulfonylurea derivatives).
- Thaum noj ib txhij nrog hydrochlorothiazide, qhov concentration ntawm fluconazole hauv cov ntshav nce ntxiv.
- Rifampicin accelerates metabolism ntawm fluconazole.
- Nyob rau hauv cov neeg mob hloov lub raum, cov tshuaj tuaj yeem ua rau nce qib plasma ntawm ciclosporin. Nrog rau qhov no hauv siab, kev saib xyuas ntawm ciclosporin concentrations yog pom zoo.
- Fluconazole nce qib plasma ntawm theophylline, midazolam thiab indinavir.
- Cov tshuaj no txhim kho cov tshuaj pharmacological ntawm rifabutin thiab phenytoin mus rau qhov tseem ceeb.
- Tshuaj nce qib tacrolimus, ua rau muaj kev pheej hmoo ntawm nephrotoxicity.
Tshuaj xyuas txog "Fluconazole Vertex"
Hnub no, yuav luag txhua tus neeg paub cov tshuaj "Fluconazole" vim nws cov txiaj ntsig zoo thiab nquag siv tshuaj los ntawm kws kho mob. Cov tshuaj los ntawm lub tuam txhab "Vertex" yog suav hais tias yog qhov zoo tshaj plaws ntawm tag nrho cov lwm yam, thiab qhov no tau lees paub los ntawm ntau cov kev tshuaj xyuas los ntawm cov neeg mob.
Cov neeg mob uas noj cov tshuaj ntsiav nco ntsoov tias cov tshuaj no ua tiav thiab kho tau sai nrog ntau hom kab mob fungal. Feem ntau ntawm lawv yog cov kab mob fungal ntawm cov mucous daim nyias nyias, nrog rau cov kab mob thrush hauv cov poj niam, qhov ncauj candidiasis, thiab lwm yam. Fluconazole yog dav siv rau cov ntsia hlau thiab ko taw fungus, thiab nyob rau hauv cov ntaub ntawv no cov tshuaj kuj pom high efficiency..
Kev tshuaj xyuas tsis zoo txog cov tshuaj vimib tug loj tus naj npawb ntawm cov kev mob tshwm sim uas tshwm sim nyob rau hauv keeb kwm yav dhau ntawm nws txais tos. Raws li qhov tshwm sim ntau zaus, tib neeg nco txog mob taub hau, mob dyspeptic, qaug zog ntau dhau thiab kiv taub hau. Feem ntau, cov neeg mob tau ntsib teeb meem digestive nyob rau hauv daim ntawv ntawm flatulence thiab cem quav.
