Nyob rau hauv tsab xov xwm, peb yuav txiav txim siab seb qhov kev npaj ntawm thioctic acid yog dab tsi.
Thioctic (α-lipoic) acid muaj peev xwm khi dawb radicals. Nws tsim nyob rau hauv lub cev tshwm sim thaum lub sij hawm oxidative decarboxylation ntawm α-keto acids. Nws koom nrog cov txheej txheem oxidative ntawm decarboxylation ntawm α-keto acids thiab pyruvic acid ua ib qho enzyme ntawm mitochondrial multienzyme complexes. Nyob rau hauv cov nqe lus ntawm biochemical kev txiav txim, cov tshuaj no yog ze rau cov vitamins ntawm pab pawg B. Thioctic acid npaj pab normalize neuronal trophism, txo cov piam thaj, nce glycogen nyob rau hauv lub siab, txo cov insulin tsis kam, txhim kho daim siab ua haujlwm, thiab ncaj qha koom nrog. Kev tswj hwm ntawm lipid thiab carbohydrate metabolism.
YPharmacokinetics
Thaum noj qhov ncauj, thioctic acid sai sai absorbed. Hauv 60 feeb, nws nce mus txog qhov siab tshaj plaws hauv lub cev. Lub bioavailability ntawm cov tshuaj yog 30%. Tom qab txhaj tshuaj ntawm thioctic acid 600 mg, cov ntshav siab tshaj plaws tau mus txog tom qab 30 feeb.
Metabolism tshwm sim hauv daim siab ntawm sab saw oxidation thiab conjugation. Cov tshuaj muaj cov cuab yeej ntawm thawj zaug dhau mus rau hauv daim siab. Kev tshem tawm ib nrab-lub neej yog 30-50 feeb (ntawm ob lub raum).
Ib daim foos
Thioctic acid yog tsim nyob rau hauv ntau hom tshuaj, tshwj xeeb tshaj yog nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj thiab cov kev daws rau infusion. Dosages kuj txawv heev nyob ntawm daim ntawv tso tawm thiab hom tshuaj.
Kev qhia
Cov lus qhia rau kev siv cov tshuaj thioctic acid tau piav qhia meej hauv cov lus qhia. Lawv raug tshuaj rau ntshav qab zib thiab cawv polyneuropathy.
YContraindications
Daim ntawv teev cov contraindications rau cov tshuaj no suav nrog:
- lactose intolerance lossis deficiency;
- galactose thiab qabzib malabsorption;
- lactation, cev xeeb tub;
- qis dua 18;
- siab rhiab heev rau cov khoom.
Kev tswj hwm cov tshuaj yuav tsum tau ua nrog ceev faj rau cov neeg muaj hnub nyoog tshaj 75 xyoo.
Cov lus qhia rau kev siv
Thioctic acid npaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj yog noj tag nrho, 30 feeb ua ntej noj tshais, nrog dej. Cov koob tshuaj pom zoo yog 600 mg ib hnub ib zaug. Noj cov ntsiav tshuaj pib tom qab ib chav kawm ntawm kev tswj hwm niam txiv kav 2-4 lub lis piam. Cov chav kawm kho mob siab tshaj plawsyog tsis ntau tshaj 12 lub lis piam. Kev kho mob ntev dua yog ua tau nrog kws kho mob cov tshuaj.
Ntsiav tshuaj rau infusion tov yog txhaj maj mam intravenously. Cov tshuaj yuav tsum tau npaj tam sim ntawd ua ntej infusion. Cov khoom npaj yuav tsum tau tiv thaiv los ntawm tshav ntuj, nyob rau hauv rooj plaub no nws tuaj yeem khaws cia ntev txog 6 teev. Kev siv daim ntawv kho mob no yog 1-4 lub lis piam, tom qab ntawd koj yuav tsum hloov mus rau ib ntsiav tshuaj.
Yuav tshuaj twg ntawm thioctic acid zoo dua, nthuav rau ntau.
Side effects
Cov kab mob hauv qab no ua rau muaj kev cuam tshuam tsis zoo thaum siv cov tshuaj no:
- ntuav, xeev siab, raws plab, mob plab, kub siab;
- tshuaj tsis haum (dawb tawv nqaij, khaus tshwm sim), anaphylactic shock;
- tseem tsis meej;
- hypoglycemia (tawm hws ntau dhau, cephalgia, kiv taub hau, qhov muag tsis pom kev);
- thrombocytopathy, purpura, petechial hemorrhages nyob rau hauv cov mucous daim nyias nyias thiab daim tawv nqaij, hypocoagulation;
- autoimmune insulin syndrome (hauv cov neeg mob ntshav qab zib);
- kub flashes, convulsions;
- nce kev ua haujlwm ntawm digestive enzymes;
- mob hauv cheeb tsam ntawm lub plawv, nrog kev qhia sai ntawm tus kws tshuaj - nce lub plawv dhia;
- thrombophlebitis;
- diplopia, qhov muag tsis pom kev;
- xav tsis xis nyob ntawm qhov chaw txhaj tshuaj, hyperemia, o.
Intracranial siab tuaj yeem nce ntxiv (ntevib leeg), ua tsis taus pa nyuaj thiab qaug zog.
Tshuaj muaj cov kua qaub no
Cov tshuaj thioctic acid ntau tshaj plaws yog:
- Berlition.
- Lipothioxon.
- Octolipen.
- Y "Thioctacid"
- Neurolipon.
- "Thiogamma".
- Polition.
- "Thiolepta".
- Espa Lipon.
Tshuaj "Berlition"
Lub ntsiab tseem ceeb ntawm cov tshuaj no yog alpha-lipoic acid, uas yog cov vitamin zoo li cov tshuaj uas ua lub luag haujlwm ntawm coenzyme hauv cov txheej txheem ntawm oxidative decarboxylation ntawm alpha-keto acids. Nws muaj antioxidant, hypoglycemic, neurotrophic teebmeem. Txo cov qib ntawm sucrose hauv cov ntshav thiab nce qhov concentration ntawm glycogen hauv daim siab, txo cov tshuaj insulin. Tsis tas li ntawd, cov khoom no tswj cov rog thiab carbohydrate metabolism, txhawb cov roj cholesterol metabolism.
Hauv cov neeg mob ntshav qab zib mellitus ntawm txhua yam, thioctic acid hloov qhov concentration ntawm pyruvic acid hauv cov ntshav, tiv thaiv cov piam thaj tso rau hauv cov hlab ntsha thiab tsim cov glycation kawg. Tsis tas li ntawd, cov kua qaub txhawb kev tsim cov glutathione, txhim kho daim siab ua haujlwm hauv cov neeg mob hepatic pathologies thiab kev ua haujlwm ntawm peripheral system hauv cov neeg mob ntshav qab zib polyneuropathy. Kev koom tes hauv cov rog metabolismthioctic acid muaj peev xwm txhawb kev tsim cov phospholipids, raws li qhov tshwm sim ntawm cov cell membranes rov qab, lub zog metabolism thiab xa cov hlab ntsha impulses yog stabilized.
Tshuaj "Lipotioxon"
Qhov kev npaj thioctic acid no yog ib hom tshuaj tiv thaiv kab mob endogenous uas khi dawb radicals. Thioctic acid plays lub luag haujlwm tseem ceeb hauv mitochondrial metabolism hauv hlwb, thiab ua raws li coenzyme hauv kev hloov pauv ntawm cov tshuaj nrog cov tshuaj tiv thaiv kab mob. Lawv tiv thaiv cov hlwb los ntawm cov radicals uas tshwm sim thaum lub sij hawm nruab nrab ntawm cov metabolism lossis thaum lub sij hawm tawg ntawm cov khoom txawv teb chaws exogenous, thiab los ntawm kev cuam tshuam ntawm cov hlau hnyav. Tsis tas li ntawd, cov khoom tseem ceeb qhia tau hais tias muaj kev sib koom ua ke nrog kev hwm ntawm insulin, uas cuam tshuam nrog kev nce hauv kev siv cov piam thaj. Hauv cov neeg mob ntshav qab zib, thioctic acid ua rau muaj kev hloov pauv ntawm pyruvic acid hauv cov ntshav.
Tshuaj "Octolipen"
Qhov no yog lwm cov tshuaj raws li thioctic acid - coenzyme ntawm ntau cov enzymatic mitochondrial pawg koom nrog hauv cov txheej txheem ntawm oxidative decarboxylation ntawm α-keto acids thiab pyruvic acid. Nws yog ib qho antioxidant endogenous: nws tshem tawm cov dawb radicals, restores qib ntawm glutathione nyob rau hauv lub hlwb, tsub kom lub functionality ntawm superoxide dismutase, axonal conduction thiab neuronal trophism. Nws ua lub luag haujlwm tseem ceeb hauv lub zog metabolism, muaj lipotropic ua haujlwm, txhim kho daim siab ua haujlwm. Nws muaj cov nyhuv detoxifying hauv hnyav hlau lom thiab lwm yam intoxications.
Cov lus qhia tshwj xeeb rau kev siv tshuaj
Thaum lub sijhawm kho nrog tshuaj raws li thioctic acid, koj yuav tsum tsis txhob haus dej cawv. Cov neeg mob ntshav qab zib yuav tsum tau saib xyuas cov ntshav qab zib kom tsis tu ncua, tshwj xeeb tshaj yog thaum pib ntawm kev siv tshuaj tshwj xeeb. Txhawm rau kom tsis txhob muaj kev txhim kho ntawm hypoglycemia, nws yuav tsum tau kho qhov koob tshuaj insulin lossis tshuaj hypoglycemic ntawm qhov ncauj. Yog tias cov tsos mob ntawm hypoglycemia tshwm sim, kev siv thioctic acid yuav tsum tau txiav tam sim ntawd. Qhov no kuj tseem siv tau rau hauv cov xwm txheej ntawm cov tshuaj tiv thaiv siab xws li pruritus thiab malaise.
Kev siv tshuaj thaum cev xeeb tub, lactation thiab menyuam yaus
Raws li cov lus piav qhia ntawm kev siv tshuaj uas muaj thioctic acid, cov tshuaj no yog contraindicated thaum cev xeeb tub thiab lactation. Kev teem caij ntawm cov nyiaj no thaum yau kuj yog contraindicated.
Drug interaction
Nws yog ib qho tsim nyog yuav tsum tau soj ntsuam ib ntus tsawg kawg 2 teev thaum siv thioctic acid nrog cov tshuaj uas muaj hlau, nrog rau cov khoom siv mis nyuj. Kev sib cuam tshuam tshuaj tseem ceeb ntawm cov kua qaub no tau pom nrog cov tshuaj hauv qab no:
- cisplatin: txo cov txiaj ntsig;
- glucocorticosteroids: txhim kho lawv cov tshuaj tiv thaiv kab mob;
- ethanol thiab nws cov metabolites: poob qisraug rau thioctic acid;
- tshuaj hypoglycemic hauv qhov ncauj thiab insulin: nce lawv cov teebmeem.
Cov khoom siv tshuaj no nyob rau hauv daim ntawv ntawm cov concentrates rau cov tshuaj infusion tsis sib haum nrog cov kev daws teeb meem ntawm dextrose, fructose, Ringer cov tshuaj, nrog rau cov kev daws teeb meem uas cuam tshuam nrog SH- thiab disulfide pawg.
Tus nqi ntawm cov tshuaj no
Tus nqi ntawm cov tshuaj uas muaj thioctic acid sib txawv heev. Kwv yees tus nqi ntawm cov ntsiav tshuaj 30 pcs. Nyob rau hauv ib koob ntawm 300 mg yog sib npaug rau - 290 rubles, 30 pcs. ntawm ib koob ntawm 600 mg - 650-690 rubles.
Cov tshuaj zoo tshaj plaws ntawm thioctic acid yuav pab koj xaiv tus kws kho mob.
tshuaj xyuas
Kev tshuaj xyuas txog tshuaj feem ntau yog qhov zoo. Cov kws tshaj lij txaus siab rau lawv cov khoom kho mob raws li neuroprotector thiab antioxidant thiab pom zoo siv cov neeg mob ntshav qab zib thiab ntau yam polyneuropathies. Ntau tus neeg mob, feem ntau cov poj niam, noj cov tshuaj no los txo qhov hnyav, tab sis cov kev xav tau muab faib rau cov txiaj ntsig ntawm cov tshuaj no rau kev poob phaus. Tseem muaj tus nqi siab ntawm cov tshuaj no.
Cov tshuaj tau txais txiaj ntsig zoo, raws li cov neeg siv khoom, cov kev mob tshwm sim tsis tshua muaj, thiab ntawm lawv, kev tsis haum tshuaj feem ntau pom, uas feem ntau mob me, cov tsos mob ploj ntawm lawv tus kheej tom qab tso tseg cov tshuaj.
Peb tau tshuaj xyuas cov npethioctic acid npaj.
