"Tamsulosin" yog ib qho tshuaj tiv thaiv dysuric thiab yog siv los ua cov tsos mob ntawm cov txheej txheem tso zis hauv cov kab mob urological uas tshwm sim los ntawm cov qog nqaij hlav tsis muaj qog nqaij hlav. Cov tshuaj tiv thaiv mechanism yog qhia nyob rau hauv ib tug maj mam txo nyob rau hauv nro nyob rau hauv cov nqaij ntshiv ntawm lub caj pas prostate, thiab nyob rau hauv lub so ntawm lub zais zis caj dab. Tsis tas li ntawd, muaj kev xaiv thaiv ntawm urethral alpha-1A-adrenergic receptors, ua rau txo qis ntawm qhov tshwm sim ntawm kev cuam tshuam - ib qho txiaj ntsig ntawm kev loj hlob ntawm adenoma.
Pharmacological nta ntawm "Tamsulosin"
Kev nqus ntawm cov khoom xyaw nquag ntawm cov tshuaj hauv plab hnyuv tuaj yeem ncav cuag 100%. Nws tau raug sim paub tseeb tias qib ntawm kev nqus tau nce ntxiv thaum cov tshuaj ntsiav tau noj tam sim tom qab noj mov. Lub degree ntawm assimilation yog proportional rau lub sij hawm dhau los txij li thaumkev siv cov tshuaj (uas yog, muaj ib tug linear kinetics). Qhov siab tshaj plaws concentration ntawm reagents nyob rau hauv cov ntshav plasma yog mus txog tom qab 6 teev (ntawm ib koob tshuaj ntawm 400 mcg). Txawm li cas los xij, lub sijhawm no yuav txawv nyob ntawm lub hnub nyoog ntawm tus neeg mob.
Nws tau sau tseg tias nrog kev kawm tsib hnub, qhov concentration ntawm cov khoom hauv plasma nce 60-70%. Tamsulosin hydrochloride nkag mus rau hauv cov txheej txheem metabolic qeeb heev: kev nqus tau nrog kev tsim cov metabolites ruaj khov, uas yog cov kev xaiv zoo rau alpha-1A-adrenergic receptors.
Cov lus qhia rau kev siv
Cov tshuaj "Tamsulosin" cov lus qhia rau kev siv cais raws li kev kho mob ntawm benign hyperplasia, symptomatic (adenoma, dysuria, lwm yam kab mob ntawm lub qis urinary tract).
Vim tias kev tshawb fawb soj ntsuam tsis tau qhia tawm qhov kev cuam tshuam tseem ceeb thaum cuam tshuam nrog lwm yam tshuaj ntawm pawg kws tshuaj, tsis muaj kev txwv txog kev siv "Tamsulosin" los ua ib qho kev pabcuam rau kev xaiv tshuaj tiv thaiv ntawm alpha-1a-adrenergic. receptors.
pom zoo ntau npaum li cas thiab siv
Qhov tsis muaj cov nyhuv antihypertensive yog cov yam ntxwv ntawm Tamsulosin. Cov lus qhia rau kev siv hais tias tsis tas yuav tsum tau xaiv koob tshuaj zoo li no - nws txaus los noj 400 mcg ntawm qhov ncauj.cov tshuaj tom qab noj tshais (2 tsiav tshuaj / ntsiav tshuaj hnyav 200 mcg txhua los yog 1 tsiav tshuaj / ntsiav tshuaj hnyav 400 mcg). Ntxiv mus, tus nqi niaj hnub no tsis tas yuav hloov kho, txawm tias tus neeg mob muaj qhov sib txawv me ntsis hauv kev ua haujlwm ntawm lub raum lossis lub siab. Txawm li cas los xij, qhov pib ntawm kev kho mob yuav tsum ua ntej los ntawm kev kuaj mob kom raug txhawm rau txhawm rau tshem tawm qhov tshwm sim ntawm prostate carcinoma. Tsis tas li ntawd, kev ntsuam xyuas qhov quav yog qhov yuav tsum tau ua thaum kho.
Cov ntsiav tshuaj thiab ntsiav tshuaj "Tamsulosin" yuav tsum tsis txhob zom - ua txhaum ntawm lub plhaub yuav ua rau muaj kev cuam tshuam rau tus nqi tso tawm cov tshuaj nquag. Tam sim ntawd tom qab noj cov tshuaj, nws raug nquahu kom haus dej. Nws yog txwv tsis pub siv "Tamsulosin" nyob rau hauv txoj hauj lwm supine.
Muaj kev txwv thiab contraindications
Cov tshuaj "Tamsulosin", tus nqi, nyob ntawm seb cov chaw tsim khoom thiab ntim hom, thaj tsam ntawm 400-1700 rubles, yog npaj tshwj xeeb rau cov txiv neej. Yog li ntawd, kev tshawb fawb txog nws cov txiaj ntsig ntawm tus menyuam hauv plab thaum cev xeeb tub tsis tau ua. Cov ntsiav tshuaj no tsuas yog sau tshuaj xwb, piv txwv li kev kuaj mob ntawm benign hyperplasia yuav tsum tau ua thaum lub sijhawm kuaj (nrog rau qhov yuav tsum tau kuaj ua ntej rau oncology).
Ntawm cov contraindications yog hypersensitivity rau cov khoom ntawm cov tshuaj "Tamsulosin" (cov lus qhia rau kev siv muaj cov ncauj lus kom ntxaws cov npe ntawm tag nrho cov.auxiliary reagents). Nws yog qhov tsis tsim nyog los siv cov tshuaj no rau orthostatic hypotension thiab mob raum lossis kab mob siab (nyob rau hauv cov xwm txheej zoo li no, tus kws kho mob tuaj koom yuav tsum tau soj ntsuam cov txiaj ntsig zoo los ntawm kev teem caij ntawm "Tamsulosin" thiab txiav txim siab txog qhov ua rau qhov tshwm sim tsis zoo ntawm kev kho mob. chav kawm).
Nrog rau kev siv tas li, kiv taub hau me ntsis yog qhov lees txais, uas qee zaum hloov los ntawm lub xeev fainting. Cov neeg tsav tsheb thiab cov neeg ua haujlwm uas nws txoj haujlwm cuam tshuam txog kev raug mob yuav tsum tau saib xyuas ntxiv thaum siv cov tshuaj no.
Side effects
Zoo li lwm yam tshuaj, Tamsulosin kuj muaj cov kev mob tshwm sim (tus nqi ntawm cov txiv neej txoj kev noj qab haus huv yog siab, thiab kev tsis haum tshuaj yog qhov tsis tseem ceeb, yog li nws tsis tsim nyog xav txog kev phiv tshuaj raws li qhov teeb meem tseem ceeb).
Ib zaug nrog cov txiaj ntsig zoo, tej zaum yuav muaj:
- mob taub hau;
- khaus tawv nqaij;
- mob raws plab;
- mob plawv arrhythmias;
- mob plab.
Qee zaum "Tamsulosin", cov analogues uas muaj nyob rau hauv khw, ua rau insomnia rau cov neeg mob los yog, conversely, tsaug zog heev. Hauv cov xwm txheej sib cais - ua txhaum ib ntus ntawm cov quav thiab ua kom tsis muaj zog.
Ntau dhau, nws qhov tshwm sim thiab qhov nruab nrab
Cov tsos mob ntawm kev noj tshuaj ntau dhau los ntawm cov tshuaj"Tamsulosin" (cov lus qhia rau kev siv ceeb toom txog qhov no), tej zaum yuav muaj pronounced mob arterial hypotension. Thiab txawm hais tias qhov tshwm sim ntawm qhov xwm txheej no tsawg heev, cov txheej txheem rau kev muab kev pab tseem suav nrog:
- tam sim ntawd muab tus neeg mob tso rau hauv txoj kab rov tav;
- yog tias tsim nyog, ua cov txheej txheem ntsuas txhawm rau ua haujlwm ntawm cov hlab plawv ntawm lub cev;
- kuaj lub raum ua haujlwm (txuas cov khoom siv tshuaj tua kabmob ntshav yog qhov ua tsis tau zoo, vim tias cov tshuaj nquag khi zoo kawg nkaus rau cov tshuaj plasma protein);
- ua kom ntuav hauv tus neeg mob txhawm rau kom tsis txhob nqus ntxiv ntawm cov tshuaj reagents (pas plab lavage nrog rau kev siv cov tshuaj laxatives kuj tseem ceeb);
- yog tias tsis muaj kev txhim kho ntawm tus mob, siv cov tshuaj uas txhawb cov ntshav ncig.
Drug Interactions: Nature of Reactions
"Warfarin" thiab "Diclofenac" zoo cuam tshuam tus nqi ntawm cov tshuaj "Tamsulosin" tawm ntawm lub cev (tus nqi ntawm cov tshuaj yog qhov ntau, tab sis qhov tshwm sim yog tsim nyog). Txawm li cas los xij, kev soj ntsuam mus sij hawm ntev txog kev siv cov tshuaj no hauv tsev kho mob tsis tau ua tiav, yog vim li cas nws thiaj li pom zoo kom siv ceev faj ntxiv. "Atenolol" thiab "Enalapril" tsis cuam tshuam nrog cov khoom teev tseg, "Cimetidine" txhawb kev nce hauv cov concentration ntawm "Tamsulosin" hauv plasma, thiab "Furosemide" muab kiag li.opposite result.
Cov txheej txheem ntawm kev txo cov ntshav siab, ua rau muaj kev cuam tshuam los ntawm kev noj tshuaj, tuaj yeem txhim kho los ntawm kev siv lwm yam alpha-1A-blockers lossis diuretics thiab tshuaj loog. Cov lus qhia rau kev siv (tus nqi ntawm cov nyiaj saum toj no yog 500-1400 rubles) tsis txiav txim siab muaj txiaj ntsig zoo ntawm cov tshuaj kinetics ntawm cov dawb feem ntawm "Diazepam" thiab "Chlormadinone" los ntawm sab ntawm cov tshuaj "Tamsulosin".
khaws cia thiab hnub tas sijhawm
Rau qhov chaw cia ntawm cov tshuaj "Tamsulosin" cov lus qhia qhia cov hauv qab no:
- kev nyab xeeb kub tswj - 15-25 degrees Celsius;
- huab cua zoo tshaj yog 70%.
Nws yog ib qho tseem ceeb uas cov khoom yuav tsum tau muab cia rau hauv nws cov thawj ntim khoom (tawm ntawm cov me nyuam ncav cuag, zoo tiv thaiv los ntawm tshav ntuj ncaj qha).
Thaum tag nrho cov lus qhia ua raws, cov chaw tsim khoom tau lees tias qhov kev kho mob ntawm "Tamsulosin" yuav tsis qaug zog li ntawm ob xyoos txij li hnub tso tawm.
Analogues ntawm cov tshuaj "Tamsulosin"
Daim ntawv teev npe "kev kawm" yog sawv cev los ntawm ob pawg tshuaj. Thawj suav nrog cov tshuaj uas feem ntau pom, qhov thib ob - tsis tshua muaj npe lag luam.
Public funds:
- "Omnic" (original - Omnic), chaw tsim tshuaj paus - Lub Netherlands, tso daim ntawv - ntsiav tshuaj / tsiav tshuaj ntawm 10/30 daim ib pob, nqi ntau - 380-1700 rubles.
- "Proflosin" (Proflosin), Lub Tebchaws Yelemees, hlwv ntawm 30 tsiav tshuaj, kwv yees tus nqi - 500 rubles.
- "Sonizin" (Sonizin), lub teb chaws ntawm keeb kwm - Romania, txheem pob ntawm 10 lossis 30 tsiav tshuaj, tus nqi nruab nrab - 450 rubles.
Lwm lub npe lag luam rau cov tshuaj "Tamsulosin" (cov lus qhia uas tsis tshua muaj, lossis cov ntawv tso tawm twb raug txiav lawm):
- "Omsulosin" (Omsulosin), Is Nrias teb, ntsiav tshuaj ntawm 0.4 mg (30 pcs.), tus nqi ntawm 350 txog 550 rubles.
- "Tamsulosin-TEVA" (Tamsulosin-TEVA), ib yam khoom ntawm lub tuam txhab "Famar-Actavis", tim Nkij teb chaws, daim ntawv ntim thiab tus nqi yog tib yam li cov ntaub ntawv dhau los.
- "Tamsulosin-Retard" ("doubler" nrog ncua kev tso tawm ntawm cov khoom), cov kab ntau lawm tsim nyob rau hauv Russia, 400 mcg ntsiav tshuaj, raug nqi txog 300-360 rubles.
"Tamsulosin": tshuaj xyuas ntawm cov kws kho mob thiab cov neeg mob
Kev kho mob siv cov tshuaj no feem ntau ua tiav thiab tau qhia nyob rau hauv qhov kev rov ua dua ntawm cov tsos mob ntawm cov qog nqaij hlav tsis zoo ntawm prostate.
Kwv yees li tom qab 90 hnub, cov tsos mob tau txo qis 2 zaug, thiab thawj qhov kev hloov pauv pom tau pom nyob rau hnub 14-21. Thaum kawg ntawm chav kawm, cov tsos mob Performance index poob los ntawm 75% (piv rau theem pib), uas yog qhov ua tau zoo.
Kev ua siab ntev ntawm cov tshuaj "Tamsulosin" (kev qhia, nqe thiabcov generics feem ntau tau nthuav tawm saum toj no) ua rau nws yooj yim heev rau siv thaum muab tshuaj kho rau cov neeg mob. Txawm li cas los xij, kom ua tiav cov txiaj ntsig siab tshaj plaws ntawm cov peev txheej ntawm cov khoom siv tsis txaus, yog li ntawd, kev kho tib yam siv lwm txoj hauv kev thiab cov khoom siv tshuaj raug pom zoo.
