APTT (lub sijhawm ua haujlwm ib nrab ntawm thromboplastin) yog ib qho tseem ceeb ntawm cov ntshav txhaws, uas tso cai rau koj los txiav txim qhov kev pheej hmoo ntawm cov ntshav txhaws lossis los ntshav. Los ntawm kev ntsuas kev ua haujlwm ntawm lub coagulation system kom raug, koj tuaj yeem txiav txim siab tias tus kab mob hnyav npaum li cas, thiab xaiv txoj kev kho kom raug. Cia peb tham.
Kev xeem APTT ua li cas?
Kev kuaj ntshav txhaws pab txhawm rau txheeb xyuas cov kab mob txawv txav, uas feem ntau qhia tau tias muaj kev ua txhaum ntawm cov ntshav ntau thiab tsis zoo.
Qhov kev tshuaj ntsuam zoo li no tau ua raws li qee lub tswv yim. Ua ntej, cov khoom yuav tsum tau kuaj xyuas yog ntxiv rau lub raj kuaj nrog cov tshuaj tiv thaiv kab mob uas khi cov calcium ions, uas tiv thaiv cov ntshav los ntawm cov ntshav. Centrifugation yog ua los cais cov ntshav los ntawm platelets thiab lwm yam khoom. Tom qab ntawd, phospholipids, calcium chloride thiab ib qho activator raug ntxiv rau hauv lub raj kuaj. Lawv pib kwv yees lub sij hawm nws yuav siv sij hawm rau cov ntshav txhaws.
Phospholipids qhib txoj hauv kev extrinsic coagulation, thiab calcium chloride yog ib qho tseem ceeb hauv cov txheej txheem.coagulation. Qhov kev soj ntsuam zoo li no tsis tso cai rau kev soj ntsuam tag nrho cov txheej txheem ntawm thrombus tsim, tab sis pab txheeb xyuas qhov sib txawv ntawm qhov nrawm txhawm rau txhawm rau nrhiav qhov ua rau muaj qhov tshwm sim.
Qee zaum nws hloov tawm tias APTT nce lossis txo qis. Qhov no qhia txog cov teeb meem uas twb muaj lawm hauv lub cev.
ntsuas ntsuas ib txwm
Qhov ntsuas ntsuas hauv vib nas this, thiab yuav txawv vim yog khoom noj khoom haus, hnub nyoog tus neeg mob thiab kev kho mob. Qhov ib txwm APTT rau tus neeg laus yog 28 mus rau 40 vib nas this. Hauv cov menyuam yug tshiab, qhov ntsuas no yog 1-3 vib nas this siab dua.
siab APTT hauv cov ntshav tau kuaj pom thaum twg cov coagulation tau txo qis lossis nce ntau dua 30%. Kev nyeem qis feem ntau qhia tias hypercoagulability.
APTT kuaj rau cov neeg laus thiab menyuam yaus yog ua kom paub qhov ua rau cov ntshav txhaws tsis zoo, nrog rau kev ntsuas qhov ua tau zoo ntawm kev kho mob anticoagulant.
Yog vim li cas thiaj nce APTT
Ntau tus chim heev thaum lawv pom tias APTT nce siab. Nws txhais li cas? Qhov no tshwm sim thaum muaj kev pheej hmoo los ntshav. Cov laj thawj rau qhov no yuav yog:
- Tsis txaus vitamin K hauv lub cev. Qhov no qhia tau hais tias muaj teeb meem nyob rau hauv lub digestive system, vim hais tias cov vitamin no txhawb lub synthesis ntawm plab hnyuv kab mob. Nws tseem yog qhov tseem ceeb rau kev ua haujlwm ib txwm muaj ntawm tag nrho cov txheej txheem txhaws. Nws tsis muaj peev xwm tshwm sim vim dysbacteriosis, nrog rau kev noj zaub mov nruj, hauvqhov tshwm sim ntawm kev kho tshuaj tua kab mob mus ntev.
- Cov noob caj noob ces uas cuam tshuam nrog kev ua txhaum ntawm qhov ntsuas qhov ntau thiab zoo ntawm cov ntshav. Hauv qhov no, APTT siab heev.
- Postpartum haemorrhage, mob leukemia, DIC.
- Hemophilia type A, B, C.
- Muaj nyob hauv cov ntshav ntawm cov tshuaj tiv thaiv kab mob tiv thaiv kab mob ntshav thiab lupus anticoagulant.
- Kev npaj tsis raug rau kev tshuaj xyuas, tso tawm ntawm heparin tsis raug rau hauv tus qauv.
Nce APTT hauv tus menyuam kuj yog vim li no.
APTT thaum cev xeeb tub
Thaum cev xeeb tub, lub sijhawm ua haujlwm ib nrab ntawm thromboplastin pib hloov. Yog hais tias tus qauv rau ib tug neeg zoo tib yam yog los ntawm 28 mus rau 40 vib nas this, rau cov poj niam cev xeeb tub nws yog 17-20 vib nas this. Qhov no txhais tau tias nws txo qis. Cov kev hloov pauv no ua rau muaj cov hauv qab no:
- Lub sijhawm nyuaj no, lub voj voog uteroplacental ntxiv ntawm cov ntshav ncig tshwm nyob rau hauv tus poj niam lub cev. Lub placenta yog tsim los ntawm ntau cov hlab ntsha. Yog hais tias txawm ib tug me me detachment tshwm sim, ces ntshav poob yuav ua tau heev tseem ceeb. Feem ntau, detachment tshwm sim vim lub suab nrov uterine.
- Thaum yug menyuam, tus poj niam feem ntau poob txog 400 ml ntawm cov ntshav. Qhov no tshwm sim sai heev, thiab cov hlab ntshav yuav tsum tau npaj kom muaj cov ntshav tsis muaj zog, yog li cov ntshav txhaws pib tsim sai heev kom tsis txhob poob ntshav ntxiv.
Vim li cas APTT nce siab thaum cev xeeb tub?
APTT nce siab yog tias lub sijhawm txhaws ntshav ntau dua 40 vib nas this. Qhov no ua rau txo qis hauv lub peev xwm los tsim cov ntshav txhaws, ua rau muaj kev pheej hmoo ntawm cov ntshav poob loj.
APTT feem ntau nce siab yog tias tus poj niam cev xeeb tub tau noj tshuaj tua kab mob, heparin, aspirin, thiab tshuaj thrombolytic. Ua ntej yuav mus kuaj, nws yuav tsum ceeb toom rau nws tus kws kho mob txog qhov no.
Kev nce hauv APTT qhia tias txo qis hauv cov ntshav txhaws, thiab qhov no tshwm sim hauv cov kab mob hauv qab no ntawm lub cev:
- kab mob siab ua rau lub siab tsis ua haujlwm hnyav, suav nrog cirrhosis. Hauv qhov no, muaj kev ua txhaum ntawm kev sib txuas ntawm cov coagulation hauv cov ntshav.
- vitamin K deficiency tshwm sim los ntawm dysbacteriosis hauv txoj hnyuv, nrog rau vim noj tsis raug.
- Leukemia.
- Hemophilia hom A, B, C. Cov no yog cov kab mob uas tshwm sim los ntawm qhov tsis muaj peev xwm ntawm cov ntshav txhaws, ua rau cov ntshav ntws tsis tu ncua.
- Willebrand kab mob.
Zoo kawg
Kev kuaj APTT yog qhov yuav tsum tau ua ua ntej yuav ua haujlwm tom ntej kom paub tias cov ntshav tuaj yeem txhaws sai npaum li cas. Kev nce lossis txo los ntawm tus qauv qhia txog ntau yam pathologies. Kev kho kom tsim nyog yog muab los tiv thaiv kev pheej hmoo los ntshav.
