"Danazol" yog ib qho tshuaj zoo uas muaj nyob rau hauv pawg kws tshuaj ntawm inhibitors pituitary hormones, hypothalamus, gonadotropins, nrog rau lawv cov antagonists. Kev siv cov tshuaj yuav tsum tau pib tsuas yog raws li cov lus qhia ntawm tus kws kho mob. Tsis tas li ntawd, koj yuav tsum ua tib zoo kawm cov lus qhia txuas nrog rau kev npaj Danazol.
Txoj kev tso tawm thiab muaj pes tsawg leeg ntawm cov tshuaj
Cov tshuaj muaj nyob rau hauv daim ntawv ntawm cov tshuaj ntsiav uas muab tso rau hauv cov pob hlwv. Lawv, nyob rau hauv lem, tau ntim rau hauv ib lub thawv ntawv.
Lwm txoj kev ntim khoom yog lub raj mis yas kaw ntom ntom nrog lub hau.
Lub ntsiab thiab tsuas yog cov khoom muaj nyob hauv cov khoom xyaw yog cov tshuaj danazol. Nws cov nqi hauv txhua lub tshuaj ntsiav yog 100 lossis 200 mg (nyob ntawm qhov ntau npaum li cas). Cov khoom pab tsis tau muab.
YPharmacokinetics
Cov tshuaj "Danazol", raws li cov lus qhia, suav nrog hauv cov npe inhibitors ntawm kev tsim cov tshuaj hormones gonadotropic. Thaum noj tsis tu ncuaKev txo qis hauv kev tsim cov tshuaj hormones pituitary FGS thiab LH ua tiav. Cov nyhuv no tau pom nyob rau hauv cov txiv neej thiab poj niam. Tib lub sijhawm, tom qab txiav cov tshuaj, cov tshuaj hormones rov qab los.
Capsules tsis muaj gestagenic thiab estrogenic kev ua, thaum muaj me ntsis androgenic kev ua si thiab anabolic nyhuv.
Nkag mus rau hauv lub cev, cov khoom xyaw nquag ua haujlwm ntau yam:
- Ovulation qeeb.
- Ectopic thiab cov ntaub so ntswg endometrial puas lawm. Raws li qhov tshwm sim ntawm cov kev hloov pauv no, cov hlwb poob lawv lub peev xwm ua haujlwm ntxiv thiab atrophy. Cov yam ntxwv zoo li no tseem ceeb hauv endometriosis.
- Pain syndrome hauv endometriosis txo qis.
- Ib qho tshuaj tiv thaiv kab mob tau tiav. Kev tswj tsis tau ntawm kev faib cov lymphocytes hauv vitro raug thaiv.
- Immunoglobulin qib txo qis.
YPharmacokinetics
Thaum nce koob tshuaj, tsis muaj kev nce ntxiv hauv bioavailability. Nyob rau tib lub sijhawm, plasma concentration tuaj yeem nce li 35-40% nrog kev nce ntxiv ntawm 2 zaug.
Ib nrab-lub neej ntawm cov khoom xyaw nquag yog li ntawm 4.5 txog 29 teev (nyob ntawm qhov ntau npaum li cas). Biotransformation ntawm cov tshuaj yog nqa tawm nyob rau hauv cov ntaub so ntswg ntawm lub siab thiab ob lub raum.
Cov lus qhia rau kev siv
Kev teem sijhawm ntawm Danazol capsules, raws li cov lus qhia, yog ua tau nyob rau hauv ob peb kis:
- endometriosis, uas yog nrog los ntawm infertility;
- primary menorrhagia;
- cov qog mis benign (nrog rau fibrocystic mastopathy);
- kos npeprecocious puberty nyob rau hauv cov me nyuam;
- gynecomastia;
- premenstrual syndrome;
- angioneurotic edema ntawm qhov xwm txheej.
"Danazol": cov lus qhia rau kev siv thiab koob tshuaj
Txoj kev kho mob thiab qhov ntau npaum li cas ntawm cov tshuaj nyob ntawm tus neeg mob qhov kev kuaj mob.
YEndometriosis. Thawj koob tshuaj txhua hnub nce mus txog 400 mg. Qhov ntim no muab faib ua 4 koob tshuaj. Thaum kho, tus kws kho mob saib xyuas cov txiaj ntsig thiab tuaj yeem txo qhov koob tshuaj txhua hnub rau 200 mg lossis nce mus rau 800 mg.
Premenstrual syndrome. Txhawm rau tshem tawm cov tsos mob, danazol 200 mg ib hnub raug muab. Qhov ntim no muab faib ua 4 koob tshuaj. Tom qab ntawd, cov tshuaj noj ib hnub tuaj yeem sib txawv ntawm 100 mg txog 400 mg.
Mastopathy. Tus qauv koob tshuaj txhua hnub ntawm cov tshuaj rau mastopathy yog 300 mg. Qhov ntim no tau muab faib ua ntau qhov txais tos. Lub sijhawm kho yuav yog 3-6 lub hlis.
Precocious puberty yog suav tias yog tib qho kev qhia uas cov menyuam raug tshuaj Danazol. Cov lus qhia thiab cov lus piav qhia ntawm cov tshuaj ntsiav qhia tias nws yuav tsum tau coj mus rau hauv tus account lub hnub nyoog thiab lub cev hnyav ntawm tus menyuam. Hauv qhov no, qhov koob tshuaj txhua hnub tuaj yeem sib txawv ntawm 100 txog 400 mg.
Thawj hnub ntawm kev noj cov tshuaj ntsiav yuav tsum coincide nrog thawj hnub ntawm kev coj khaub ncaws nyob rau hauv cov poj niam. Lub sijhawm ntawm kev kho mob nyob ntawm qhov kev kuaj mob, tab sis tsis tuaj yeem tshaj 6 lub hlis.
YContraindications
Koj yuav tsum tau sau cov tshuaj no nrognoj mus rau hauv tus account lub uas twb muaj lawm contraindications. Hauv daim ntawv teev npe no:
- lub sijhawm cev xeeb tub thiab lactation;
- qhov chaw mos los ntshav;
- malignant qog ntawm prostate thiab mis;
- porphyria;
- mob raum tsis ua haujlwm;
- daim siab tsis ua haujlwm thiab lwm yam kab mob siab heev;
- mob vwm;
- mob hemostasis;
- migraine;
- lub plawv tsis ua hauj lwm;
- mob vwm.
Side effects
Tsis yog txhua tus neeg tsim nyog noj cov tshuaj Danazol. Los ntawm cov lus qhia rau kev siv thiab kev tshuaj xyuas tus neeg mob, koj tuaj yeem paub txog qhov muaj ntau ntawm cov kev mob tshwm sim.
Digestive system. Ntawm no, cov tsos mob ntawm kev ua haujlwm ntawm lub plab zom mov yog ua tau. Kev kuaj mob tuaj yeem nthuav tawm cov haujlwm ntawm daim siab enzymes.
YEndocrine system. Kev kho mob tuaj yeem nrog:
- flushing;
- amenorrhea;
- tawm hws hnyav;
- ntshai;
- cim pob txuv;
- low libido;
- ua kom muaj zog ntawm cov qog sebaceous;
- edema;
- kos npe ntawm hirsutism;
- hnyav nce;
- pathologies ntawm spermatogenesis.
Central paj hlwb. Cov npe ntawm cov tshuaj tiv thaiv feem ntau suav nrog kiv taub hau, mob taub hau, kev nyuaj siab, pw tsaug zog, tshee hnyo, kev xav tsis muaj zog.
Dermatology. Nrog tus kheej intolerance, tawv nqaijpob.
Cov kab mob plawv. Muaj tsawg zaus, arterial hypertension thiab tachycardia tuaj yeem tshwm sim.
Koj kuj tseem tuaj yeem hnov mob nraub qaum, cramps lossis cov leeg nqaij spasms, pom kev cuam tshuam.
Yog cov tsos mob saum toj no tshwm sim, koj yuav tsum tsum tsis txhob noj tshuaj thiab sab laj nrog kws kho mob kom kho.
Ntau tshaj
Yog tias tus neeg mob noj "Danazol" raws li cov lus qhia, kev noj tshuaj ntau dhau yuav raug cais tawm. Yog tias cov koob tshuaj tau pom zoo dhau lawm, cov tsos mob hauv qab no tshwm sim:
- nausea;
- ntua;
- kiv taub hau;
- mob taub hau;
- txhawj xeeb;
- tremor.
Nrog rau qhov tshwm sim, koj yuav tsum hu rau lub tsheb thauj neeg mob tam sim ntawd. Cov kws kho mob ua ntej ua plab hnyuv, tom qab uas cov tsos mob tau sau tseg.
Kev sib cuam tshuam nrog lwm yam tshuaj
Nws yog ib qho tseem ceeb heev los kawm txog kev cuam tshuam ntawm Danazol hauv cov lus qhia rau kev siv. Nrog endometriosis, benign mis hlav thiab lwm yam kab mob, cov tshuaj yog muab raws li ib feem ntawm txoj kev kho.
Nrog insulin. Ib qho tshuaj hormone inhibitor txo qis kev ua haujlwm ntawm insulin. Qhov no tuaj yeem ua rau muaj ntshav qabzib ntau ntxiv. Txhawm rau zam qhov no, kev hloov kho koob tshuaj ntawm cov tshuaj hypoglycemic raug pom zoo.
Nrog indirect anticoagulants. Cov nyhuv kho ntawm cov tshuaj no yog txhim kho. Nyob rau tib lub sij hawm, lub siab synthesis ntawm procoagulant yam txo qis thiab muaj kev pheej hmooqhib los ntshav.
Nrog carbamazepine. Muaj qhov txaus ntshai ntawm inhibition ntawm cov metabolism hauv carbamazepine, uas ua rau muaj kev nce hauv cov concentration ntawm cov tshuaj hauv cov ntshav (cov nyhuv tshuaj lom).
Nrog cov tshuaj tiv thaiv kab mob (xws li Phenobarbital thiab Phenytoin). Cov nyhuv ntawm cov tshuaj no yog txhim khu kev qha.
cuam tshuam rau kev tsav tsheb
Cov tshuaj "Danazol" - raws li cov lus qhia thiab tshuaj xyuas ntawm cov neeg mob - tsis cuam tshuam rau lub peev xwm tsav tsheb lossis cov txheej txheem nyuaj. Txawm li cas los xij, cov npe ntawm cov kev mob tshwm sim suav nrog cov tsos mob xws li kiv taub hau thiab qhov muag tsis pom kev. Yog li ntawd, koj yuav tsum ceev faj thaum tsav tsheb.
Cov lus qhia tshwj xeeb
Nyob rau hauv lub xub ntiag ntawm thawj hypoparathyroidism, cov tshuaj no yuav ua rau hypercalcemia yog tias tus neeg mob noj alfacalcidol.
Thaum muab tshuaj gonadotropic hormone inhibitor, tus kws kho mob yuav tsum kuaj xyuas cov qib bilirubin thiab daim siab transaminases.
Cov neeg mob ntshav qab zib yuav tsum tau kho lawv cov koob tshuaj danazol thiab insulin.
Analogues
Nws tshwm sim tias cov tshuaj tsis haum rau tus neeg mob. Hauv qhov no, cov kws kho mob tuaj yeem hloov Danazol. Analogues tsis tau qhia hauv cov lus qhia rau kev siv tshuaj, thiab qee cov neeg mob ua rau lawv tus kheej txaus ntshai thiab pheej hmoo, uas yav tom ntej hloov mus ua teeb meem kev noj qab haus huv ntau dua. Cov tshuaj analogues muab faib ua 2 pawg:
- Tshuaj zoo sib xws hauv cov khoom xyaw nquag. Cov tshuaj danazol muaj nyob rau hauv cov tshuaj xws li Danol, Vero-Danazol, Danodiol, Danogen thiab Danoval.
- Cov tshuaj sib txawv hauv cov khoom sib txawv tab sis muaj cov txiaj ntsig zoo sib xws. Cov npe no suav nrog Klimadinon Uno, Nemestran, Remens, Onagris.
Nws yog txwv tsis pub txiav txim siab hloov tshuaj ntawm koj tus kheej. Qhov no yog vim lub fact tias cov lus qhia rau Danazol thiab cov lus qhia rau analogues txawv. Ib hom tshuaj sib txawv yuav xav tau kev kho mob sib txawv.
Kev tshuaj xyuas los ntawm cov neeg mob thiab kws kho mob
Txawm hais tias muaj ntau qhov kev phiv tshwm sim, ntau tus neeg mob tau txaus siab rau cov nyhuv ntawm cov tshuaj. Qee tus poj niam nco ntsoov tias lawv qhov kev kuaj mob ntawm endometriosis tau nrog kev xeeb tub. Tom qab kawm tiav ntawm kev kho mob nrog Danazol, lub siab xav tau kev sib deev tau rov qab los, kev kuaj mob raug tshem tawm thiab kev ua haujlwm ntawm menyuam rov qab los.
Cov kws kho mob qhia cov tshuaj no ua ib qho txiaj ntsig zoo tshaj plaws ntawm pawg tshuaj no. Feem ntau, cov kev kho mob tau txais txiaj ntsig zoo los ntawm cov neeg mob. Txhawm rau tshem tawm cov kev mob tshwm sim, nws yuav txaus los txo cov tshuaj noj txhua hnub ntawm cov tshuaj.
Tib lub sijhawm, cov kws kho mob hais txog: hauv txhua kis, tus kws kho mob tuaj koom xaiv ib tus neeg kho raws li ntau qhov ntsuas. Vim li no, kev tswj tus kheej ntawm cov tshuaj no raug txwv.
