Tshuaj uas tswj lub cev cov txheej txheem metabolic sawv cev rau ib pawg ntawm cov tshuaj uas tau siv los kho ntau yam kab mob. Thiab txawm hais tias cov kab lus no tsis zoo li tsis meej thiab tsis muaj qab hau, nws yeej yog. Txhua yam kab mob, txhua yam txheej txheem pathological tshwm sim hauv peb lub cev yog nrog los ntawm kev ua txhaum ntawm cov txheej txheem metabolic tshwm sim ntawm qib cell. Thiab nws yog kev kho ntawm cov kab mob metabolic uas, feem ntau, ua rau rov qab los. Ib qho tshuaj uas siv los kho cov teeb meem no hauv lub cev yog Asparkam. Nws yog tshuaj rau ntau yam pathologies. Cia peb saib ntawm "Asparkam", analogues ntawm cov tshuaj uas siv niaj hnub no.
Cov yam ntxwv ntawm cov tshuaj "Asparkam"
Raws li twb tau hais lawm, cov tshuaj "Asparkam" belongs rau pawg tshuaj uas cuam tshuam rau cov txheej txheem metabolic ntawm lub cev. Lub mechanism ntawm kev txiav txim ntawm cov tshuajraws li cov ntsiab lus hauv qab no.
Qhov xav tau los tswj qhov tsis tu ncua ntawm ionic muaj pes tsawg leeg ntawm ib puag ncig intracellular yog dav paub. Nyob rau tib lub sijhawm, kev saib xyuas tshwj xeeb hauv cov txheej txheem ntawm cov cell metabolism yog them rau cov poov tshuaj thiab magnesium ions. Vim lub peev xwm ntawm lub npe hu ua asparginates (uas yog ib feem ntawm cov tshuaj no) los koom rau hauv cov txheej txheem ntawm intracellular ion thauj, kev taw qhia ntawm "Asparkam" pab kom lawv cov concentration thiab txhim kho cell metabolism.
Vim qhov tseeb tias lub plawv yog lub hauv paus tseem ceeb uas cuam tshuam rau qhov tsis txaus ntawm ions (tshwj xeeb tshaj yog cov poov tshuaj ions), Asparkam nthuav tawm cov txiaj ntsig cardioprotective los ntawm kev tshem tawm ion tsis txaus hauv cardiomyocytes. Qhov no, nyob rau hauv lem, yog manifested los ntawm ib tug txo nyob rau hauv cov txheej txheem ntawm excitability thiab conductivity, uas yog reflected nyob rau hauv lub antiarrhythmic nyhuv ntawm cov tshuaj.
Vim qhov cuam tshuam rau cov ntsiab lus ntawm magnesium ions, "Asparkam" cuam tshuam rau sodium-potassium cellular twj tso kua mis, txo intracellular sodium concentration thiab txhawb cov txheej txheem ntawm repolarization ntawm cell membrane. Ib qho kev nce hauv daim nyias nyias ua rau qhov tseeb tias me me ntawm calcium ions nyob hauv cytoplasm, koom nrog cov txheej txheem ntawm electromechanical coupling ntawm actin thiab myosin hauv cardiomyocytes.
Tsis tas li ntawd, aspartate, uas yog ib feem ntawm cov tshuaj, txhawb kev ua haujlwm ntawm cov txheej txheem metabolic, nce tsis tsuas yog amino acid synthesis, tab sis kuj yog cov synthesis ntawm amino qab zib thiab lipids,koom nrog hauv kev tswj hwm ntawm intracellular metabolism. Qhov xwm txheej no pab txhawb kev txhim kho lub zog metabolism hauv cov ntaub so ntswg ischemic thiab thaj chaw ntawm myocardium. "Panangin" - ib qho analogue ntawm "Asparkam" - vim yog cov ntsiab lus zoo tib yam ntawm cov poov tshuaj thiab magnesium aspartate, nws nthuav tawm tib cov tshuaj pharmacodynamic. Qhov xwm txheej no ua rau muaj qhov yuav luag zoo sib xws ntawm "Panangin" hauv kev xyaum cardiology.
Pharmacokinetic nta
"Asparkam" nws tus kheej, analogues ntawm cov tshuaj no sai thiab yuav luag tag nrho nkag mus rau hauv lub cev. Excretion ntawm cov tshuaj tshwm sim tsuas yog nrog kev pab los ntawm ob lub raum. Tom qab ib koob tshuaj, qhov siab tshaj plaws ntawm cov tshuaj hauv cov hlab ntsha tau mus txog tom qab 1-2 teev. Los ntawm cov hlab ntsha, "Asparkam" nkag mus rau hauv cov hlwb hauv daim ntawv ntawm cov poov tshuaj, magnesium thiab aspartate ions thiab pib koom nrog lawv cov txheej txheem metabolic.
Cov lus qhia rau kev siv
Daim ntawv ntsiav tshuaj ntawm Asparkam yog npaj (thiab siv tau zoo) rau kev kho mob ntawm cov kab mob plawv. Yog li, cov lus qhia rau kev muab tshuaj yuav yog cov mob tom qab mob, cov xwm txheej tom qab cardioversion, los yog nrog rau kev ua txhaum ntawm lub atherosclerosis thiab conduction ntawm myocardium. "Asparkam" yog zoo nyob rau hauv txoj kev kho mob ntawm lub plawv tsis ua hauj lwm nrog kev siv ntawm cardiac glycosides, raws li zoo raws li nyob rau hauv cov xwm txheej ntawm overdose los yog lom nrog saluretics (cov tshuaj diuretic uas, ntxiv rau kom diuresis, nce excretion ntawm ions los ntawm lub cev)..
Daim ntawv txhaj tshuaj ntawm "Asparkam" tau siv tiav ua ib feem ntawm txoj kev kho mob ntawm lub plawv tsis ua haujlwm ntev, suav nrog tom qab myocardial infarction, nrog kev sib dhos thiab kev cuam tshuam, ua ib feem ntawm txoj kev kho mob.
Contraindications rau sau tshuaj
Vim qhov tseeb tias Asparkam muaj ntau ntawm magnesium thiab poov tshuaj ions, nws yog contraindicated nyob rau hauv mob thiab mob raum tsis ua hauj lwm, thiab nyob rau hauv cov ntaub ntawv ntawm hypersensitivity rau ib los yog ntau yam ntawm cov tshuaj no.
Hauv kev poob siab cardiogenic (thaum systolic ntshav siab poob qis dua 90 mm Hg), nws tsis pom zoo kom siv "Asparkam", analogues. Cov lus qhia rau kev siv qhia tau hais tias cov tshuaj kuj yog contraindicated nyob rau hauv Addison tus kab mob thiab ua hauj lwm tsis txaus ntawm cov qog adrenal, nyob rau hauv cov ntaub ntawv uas tus neeg mob muaj ib tug high-degree atrioventricular block thiab muaj cov ntsiab lus ntawm cov poov tshuaj thiab magnesium ions nyob rau hauv cov ntshav plasma.
Txoj kev tswj hwm thiab noj ntau npaum li cas
Thaum siv cov ntsiav tshuaj daim ntawv ntawm cov tshuaj "Asparkam" noj ib los yog ob ntsiav tshuaj tom qab noj peb zaug ib hnub twg. Lub sijhawm ntawm kev kho mob yog txiav txim los ntawm tus kws kho mob koom nrog raws li kev kho mob ntawm tus kab mob thiab cov ntaub ntawv los ntawm kev sim thiab ntsuas cov txheej txheem tshawb fawb.
Daim ntawv txhaj tshuaj yog rau kev siv cov hlab ntsha nkaus xwb. Cov ntsiab lus ntawm ib ampoule yuav tsum tau yaj nyob rau hauv 50 los yog 100 ml ntawm sterileisotonic qabzib tov, muab intravenously drip maj mam. Kev rov qhia dua tuaj yeem rov ua dua tsis pub dhau 4-6 teev tom qab kev teem sijhawm dhau los ntawm cov tshuaj "Asparkam". Analogues ntawm cov tshuaj no (piv txwv li, Panangin) raug tshuaj ib yam. "Panangin", zoo li "Asparkam", muaj kev cuam tshuam rau cov metabolism hauv myocardiocytes. Yog li ntawd, qhov analogue ntawm "Asparkam" nyob rau hauv Russia yog dav siv nyob rau hauv cov tsev kho mob plawv.
Side effects
Nyob rau hauv cov ntaub ntawv ntawm kev noj cov ntsiav tshuaj, cov kab mob ntawm txoj hnyuv yuav tshwm sim, uas tshwm sim los ntawm qhov mob thiab kub hnyiab nyob rau hauv lub epigastric cheeb tsam, xeev siab, thiab ntuav. Kev siv mus sij hawm ntev tuaj yeem ua rau muaj qhov tsis xws luag hauv mucosal.
Vim cov tshuaj muaj feem cuam tshuam rau cov hlab plawv, arrhythmias, kev cuam tshuam ntawm kev ua haujlwm, atrioventricular blockades, txo cov ntshav siab tuaj yeem tshwm sim ntawm nws qhov.
Nyob rau ntawm lub paj hlwb, qhov tshwm sim ntawm paresthesia, tingling sensations, convulsions yog sau tseg.
Vim yog cov ntsiab lus siab ntawm magnesium ions thiab lawv nkag mus rau hauv lub hauv nruab nrab paj hlwb, kev ua pa ntawm lub ntsws yuav inhibited. Tsis tas li ntawd feem ntau muaj kev xav ntawm tshav kub nrog kev qhia txog cov tshuaj "Asparkam". Analogues ntawm cov tshuaj no muaj cov tsos mob zoo sib xws ntawm cov kev phiv tshwm sim thiab zaus ntawm lawv qhov tshwm sim. Raws li qhov pom ntawm qhov no, nws yog ib qho tsim nyog yuav tsum nug tus neeg mob txog kev noj cov tshuaj no yav dhau los.nyiaj.
cov lus qhia tshwj xeeb rau kev siv tshuaj "Asparkam"
Analogues rau cov menyuam yaus tau siv dav hauv kev xyaum menyuam yaus, txawm hais tias tam sim no muaj cov ntaub ntawv tsis txaus ntawm kev siv "Asparkam" hauv cov menyuam yaus. Txawm li cas los xij, cov tshuaj tau ua tiav siv los kho cov kab mob plawv hauv cov menyuam yaus.
Nrog rau kev siv Asparkam ntev, nws raug nquahu kom ua tib zoo saib xyuas cov electrolyte muaj pes tsawg leeg ntawm cov ntshav plasma, tswj cov ntsuas electrocardiographic. Tsis tas li ntawd, nrog kev ceev faj heev, cov tshuaj yog siv rau cov neeg mob uas muaj ntshav plasma poov tshuaj ntau ntau.
Asparkam: analogues
Ntawm cov generics uas twb muaj lawm ntawm Asparkam nyob rau hauv lub khw muag tshuaj, nws yog tsim nyog hais txog Panangin. Muaj kev ua haujlwm siab, qhov analogue ntawm "Asparkam" yog dav siv nyob rau hauv Russia, raws li nws muaj ib tug zoo tib yam muaj pes tsawg leeg thiab, raws li, zoo sib xws indications rau siv. Thiab kev xyaum ntawm cardiology yog ib qho piv txwv ntawm qhov no. Yog li, "Panangin" yog ib qho analogue ntawm "Asparkam" nrog tib lub ntsiab lus.
Nrog rau lwm cov tshuaj uas muaj cov nyhuv zoo sib xws, nws yuav tsum raug sau tseg "Inosine", "Riboxin", "Meksaritm", "Propanorm", "Rhythmocard".
